Quillivant Xr

  • ADHD

Quillivant Xr Generic Name & Formulations

General Description

Methylphenidate HCl ext-rel 5mg/mL; pwd for oral susp after reconstitution.

Pharmacological Class

CNS stimulant.

How Supplied

Bottles (w. oral dosing dispenser)—60mL, 120mL, 150mL, 180mL


Generic Availability


Quillivant Xr Indications


Attention deficit hyperactivity disorder.

Quillivant Xr Dosage and Administration

Adults and Children

<6yrs: not established. ≥6yrs: Individualize. Shake bottle for 10 secs before use. Initially 20mg once daily in the AM. May increase by 10–20mg per week if needed; max 60mg daily. Discontinue if no improvement seen after dose adjustment over 1 month. Switching from other methylphenidate products: discontinue and follow Quillivant XR titration schedule.

Quillivant Xr Contraindications


During or within 14 days of MAOIs.

Quillivant Xr Boxed Warnings

Boxed Warning

Abuse and dependence.

Quillivant Xr Warnings/Precautions


Do not substitute for other methylphenidate products on a mg-per-mg basis. High potential for abuse and dependence; monitor. Increased risk of sudden death, stroke, and MI; assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, and other cardiac problems. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors in developing manic episode prior to initiating. Consider discontinuing if new psychotic or manic symptoms occur. Peripheral vasculopathy, including Raynaud's phenomenon; monitor for digital changes. Monitor growth (in children), BP, HR. Reduce dose or discontinue if paradoxical aggravation of symptoms occurs. Write ℞ for smallest practical amount. Reevaluate periodically. Pregnancy. Nursing mothers: monitor infants.

Quillivant Xr Pharmacokinetics

See Literature

Quillivant Xr Interactions


See Contraindications. Hypertensive crisis with MAOIs. May antagonize antihypertensive agents; monitor and adjust dose of antihypertensives as needed. Concomitant risperidone may increase risk of extrapyramidal symptoms; monitor.

Quillivant Xr Adverse Reactions

Adverse Reactions

Appetite decreased, insomnia, nausea, vomiting, dyspepsia, abdominal pain, weight decreased, anxiety, dizziness, irritability, affect lability, tachycardia, hypertension; priapism.

Quillivant Xr Clinical Trials

See Literature

Quillivant Xr Note

Not Applicable

Quillivant Xr Patient Counseling

See Literature