• Anesthetics

Quelicin Generic Name & Formulations

General Description

Succinylcholine chloride 20mg/mL, 100mg/mL; soln for IM or IV inj.

Pharmacological Class

Skeletal muscle relaxant (depolarizing).

How Supplied

Single-dose vials 100mg/mL (10mL)—25 (preservative-free); Multi-dose vials 20mg/mL (10mL)—25


Quelicin Indications


Adjunct to general anesthesia to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Quelicin Dosage and Administration


Individualize. Patients homozygous for atypical plasma cholinesterase gene: give test dose of 5–10mg (1mg/mL solution) by slow IV infusion. Short surgical (tracheal intubation): usual dose: 0.6mg/kg IV; range: 0.3–1.1mg/kg IV. Long surgical: (1–2mg/mL solution) by continuous infusion given at a rate of 2.5–4.3mg/min; alternatively by intermittent IV inj: initially 0.3–1.1mg/kg, followed by 0.04–0.07mg/kg. If suitable vein is inaccessible, may give by IM inj: up to 3–4mg/kg, max 150mg total dose.


See full labeling. Emergency tracheal intubation: infants and small children: 2mg/kg IV; older pediatric patients and adolescents: 1mg/kg IV. If suitable vein is inaccessible, may give by IM inj: up to 3–4mg/kg, max 150mg total dose.

Quelicin Contraindications


Skeletal muscle myopathies. Acute phase of injury following major burns, multiple trauma, extensive denervation of skeletal muscle, or upper motor neuron injury. Genetic susceptibility to malignant hyperthermia.

Quelicin Boxed Warnings

Boxed Warning

Ventricular dysrhythmias, cardiac arrest, and death from hyperkalemic rhabdomyolysis in children.

Quelicin Warnings/Precautions


To be administered only by those skilled in management of artificial respiration. Have intubation, adequate ventilation, oxygen therapy available. Should not be administered prior to induction of unconsciousness (unless emergency). Pretreatment with anticholinergic agents (eg, atropine) may reduce bradyarrythmias. Risk of prolonged neuromuscular block in reduced plasma cholinesterase activity. Plasma cholinesterase activity may be diminished in presence of gene abnormalities (eg, heterozygous or homozygous for atypical plasma cholinesterase gene), pregnancy, severe hepatic or renal disease, malignant tumors, infections, burns, anemia, heart disease, peptic ulcer, myxedema, or drugs affecting cholinesterase activity (see Interactions). Electrolyte abnormalities, digitalis toxicity, acute phase of injury (see Contraindications), chronic abdominal infection, subarachnoid hemorrhage, or conditions causing degeneration of central and peripheral nervous systems: increased risk of hyperkalemia. Hypokalemia or hypocalcemia (neuromuscular blockade may be prolonged). Risk of malignant hyperthermia; discontinue all triggering agents if suspected (eg, volatile anesthetic agents, succinylcholine). Risk of medication errors; confirm proper selection of intended product and ensure dose is clearly labeled/communicated. Monitor for possible transition into Phase II block (see full labeling). Glaucoma or eye injury. Bone fractures or muscle spasm. Elderly. Pregnancy. Labor & delivery. Nursing mothers.

Quelicin Pharmacokinetics



Quelicin Interactions


Potentiated by promazine, oxytocin, aprotinin, certain non-penicillin antibiotics, quinidine, β-adrenergic blockers, procainamide, lidocaine, trimethaphan, lithium carbonate, magnesium salts, quinine, chloroquine, isoflurane, desflurane, metoclopramide, terbutaline, chronically administered oral contraceptives, glucocorticoids, certain MAOIs, organophosphates, ecothiophate, and certain antineoplastics. Antagonized by anticholinergics.

Quelicin Adverse Reactions

Adverse Reactions

Cardiac arrest, malignant hyperthermia, arrhythmias, bradycardia, tachycardia, hyper- or hypotension, hyperkalemia, prolonged respiratory depression or apnea, increased intraocular pressure, increased intragastric pressure, muscle fasciculation, jaw rigidity, post-op muscle pain, rhabdomyolysis with possible myoglobinuric acute renal failure, excessive salivation, rash, hypersensitivity reactions.

Quelicin Clinical Trials

See Literature

Quelicin Note

Not Applicable

Quelicin Patient Counseling

See Literature