Tuberculosis:
Indications for: Pyrazinamide
Susceptible pulmonary tuberculosis.
Adults and Children:
15–30mg/kg once daily; max 2g daily. Or 50–70mg/kg twice weekly based on lean body weight.
Pyrazinamide Contraindications:
Severe hepatic damage. Acute gout.
Pyrazinamide Warnings/Precautions:
Use with other antituberculars. Monitor hepatic function and serum uric acid before and during therapy. Hepatocellular damage or hyperuricemia with acute gouty arthritis: discontinue. Patients at risk for hepatitis (eg, alcoholism). Diabetes (blood glucose may be harder to control). HIV: see literature. Pregnancy (Cat.C). Nursing mothers.
Pyrazinamide Classification:
Nicotinamide analogue.
Pyrazinamide Interactions:
May interfere with Acetest or Ketostix.
Adverse Reactions:
Hepatitis, liver dysfunction, gout, GI disturbances, arthralgia, myalgia, blood dyscrasias (rare).
How Supplied:
Contact supplier.
