• Tuberculosis

Pyrazinamide Generic Name & Formulations

General Description

Pyrazinamide 500mg; scored tabs.

Pharmacological Class

Nicotinamide analogue.

How Supplied

Contact supplier.

Pyrazinamide Indications


Susceptible pulmonary tuberculosis.

Pyrazinamide Dosage and Administration

Adults and Children

15–30mg/kg once daily; max 2g daily. Or 50–70mg/kg twice weekly based on lean body weight.

Pyrazinamide Contraindications


Severe hepatic damage. Acute gout.

Pyrazinamide Boxed Warnings

Not Applicable

Pyrazinamide Warnings/Precautions


Use with other antituberculars. Monitor hepatic function and serum uric acid before and during therapy. Hepatocellular damage or hyperuricemia with acute gouty arthritis: discontinue. Patients at risk for hepatitis (eg, alcoholism). Diabetes (blood glucose may be harder to control). HIV: see literature. Pregnancy (Cat.C). Nursing mothers.

Pyrazinamide Pharmacokinetics

See Literature

Pyrazinamide Interactions


May interfere with Acetest or Ketostix.

Pyrazinamide Adverse Reactions

Adverse Reactions

Hepatitis, liver dysfunction, gout, GI disturbances, arthralgia, myalgia, blood dyscrasias (rare).

Pyrazinamide Clinical Trials

See Literature

Pyrazinamide Note

Not Applicable

Pyrazinamide Patient Counseling

See Literature