Protriptyline Hcl

  • Mood disorders

Protriptyline Hcl Generic Name & Formulations

General Description

Protriptyline HCl 5mg, 10mg; tabs.

Pharmacological Class


How Supplied

Contact supplier.

Protriptyline Hcl Indications



Protriptyline Hcl Dosage and Administration


15–40mg daily in 3–4 divided doses. Increase AM dose if needed; max 60mg daily. Elderly, adolescents: initially 5mg 3 times daily.


Not established.

Protriptyline Hcl Contraindications


During or within 14 days of MAOIs. Concomitant cisapride. Acute post-MI.

Protriptyline Hcl Boxed Warnings

Not Applicable

Protriptyline Hcl Warnings/Precautions


Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor for clinical worsening or unusual changes. History of seizures. Urinary retention. Increased intraocular tension. Angle-closure glaucoma. Cardiovascular disorders. Bipolar disorder. Mania. Psychosis. ECT. Diabetes. Hyperthyroidism. Liver disorders. Discontinue prior to surgery. Poor metabolizers (CYP2D6). Avoid abrupt cessation. Avoid sun, UV light. Elderly (monitor cardiovascular effects over 20mg/day). Pregnancy. Nursing mothers.

Protriptyline Hcl Pharmacokinetics

See Literature

Protriptyline Hcl Interactions


See Contraindications. Hyperpyretic crisis, convulsions, death with MAOIs. Avoid during or within 5 weeks of fluoxetine. Potentiates alcohol, CNS depressants. Blocks guanethidine. Paralytic ileus, hyperpyrexia with anticholinergics, neuroleptics. Potentiated by CYP2D6 inhibitors (eg, quinidine, phenothiazines, SSRIs, propafenone, flecainide); monitor with cimetidine. Adjust sympathomimetic, anticholinergic doses. Increased seizure risk with tramadol.

Protriptyline Hcl Adverse Reactions

Adverse Reactions

CNS, anticholinergic, or cardiovascular effects (eg, drowsiness, confusion, anxiety, tachycardia, hypotension), extrapyramidal symptoms, nausea, fatigue, rash, headache, changes in blood sugar, photosensitivity, edema, blood dyscrasias, sexual dysfunction, gynecomastia, liver dysfunction.

Protriptyline Hcl Clinical Trials

See Literature

Protriptyline Hcl Note


Formerly known under the brand name Vivactil.

Protriptyline Hcl Patient Counseling

See Literature