Protamine Sulfate

  • Poisoning/overdose

Protamine Sulfate Generic Name & Formulations

General Description

Protamine sulfate 10mg/mL; soln for inj; preservative-free.

Pharmacological Class

Heparin antagonist.

How Supplied

Vial (5mL)—25; 25mL—1


Protamine Sulfate Indications


Heparin overdose.

Protamine Sulfate Dosage and Administration


Give by slow IV inj over 10mins. Determine dose by coagulation studies; dose requirement decreases with time elapsed after heparin administration. 1mg neutralizes ≥100units of heparin; max 50mg/dose.


Not recommended.

Protamine Sulfate Contraindications

Not Applicable

Protamine Sulfate Boxed Warnings

Not Applicable

Protamine Sulfate Warnings/Precautions


Avoid rapid administration. Fish allergy. Previous exposure to protamine (including insulin). Severe left ventricular dysfunction. Abnormal pulmonary hemodynamics. Previous vasectomy. Pregnancy (Cat.C). Nursing mothers.

Protamine Sulfate Pharmacokinetics

See Literature

Protamine Sulfate Interactions


Incompatible with certain antibiotics (eg, cephalosporins, penicillins).

Protamine Sulfate Adverse Reactions

Adverse Reactions

Hypotension, bradycardia, transient flushing, feeling of warmth, dyspnea, GI upset, lassitude, pulmonary edema, anaphylaxis, cardiovascular collapse, pulmonary vasoconstriction, pulmonary hypertension.

Protamine Sulfate Clinical Trials

See Literature

Protamine Sulfate Note

Not Applicable

Protamine Sulfate Patient Counseling

See Literature