Prostin Vr Pediatric

  • CHF and arrhythmias

Prostin Vr Pediatric Generic Name & Formulations

General Description

Alprostadil 500mcg/mL; soln for IV infusion after dilution; contains dehydrated alcohol.

Pharmacological Class

Prostaglandin E1.

How Supplied

Ampules (1mL)—5


Prostin Vr Pediatric Indications


Palliative therapy to maintain ductus arteriosus patency until corrective or palliative surgery can be performed in neonates with congenital heart defects and who depend on patent ductus for survival.

Prostin Vr Pediatric Dosage and Administration


Not applicable.


Use lowest effective dose for shortest duration. Give by continuous IV infusion into large vein (preferred) or through an umbilical artery catheter placed at the ductal opening. Initially 0.05–0.1mcg/kg/min. Reduce dose from 0.1 to 0.05 to 0.025 to 0.01mcg/kg/min after therapeutic response is achieved to provide lowest dose that maintains response. If inadequate response to 0.05mcg/kg/min; may increase up to 0.4mcg/kg/min.

Prostin Vr Pediatric Contraindications

Not Applicable

Prostin Vr Pediatric Boxed Warnings

Boxed Warning

Apnea in neonates with congenital heart defects; use where ventilatory assistance is immediately available.

Prostin Vr Pediatric Warnings/Precautions


Respiratory distress syndrome: not recommended. Bleeding disorders. Prolonged therapy (>120hrs): monitor for antral hyperplasia and gastric outlet obstruction. Monitor respiratory status, arterial pressure, blood oxygenation, BP, blood pH; decrease infusion rate if arterial pressure falls significantly. Neonates <2kg at birth.

Prostin Vr Pediatric Pharmacokinetics

See Literature

Prostin Vr Pediatric Interactions


Caution with anticoagulants.

Prostin Vr Pediatric Adverse Reactions

Adverse Reactions

Apnea, fever, flushing, bradycardia, hypotension, tachycardia, seizures, diarrhea, sepsis, cortical proliferation of the long bones (long-term infusion).

Prostin Vr Pediatric Clinical Trials

See Literature

Prostin Vr Pediatric Note

Not Applicable

Prostin Vr Pediatric Patient Counseling

See Literature