Prostin E2

  • Miscellaneous Ob/Gyn conditions

Prostin E2 Generic Name & Formulations

General Description

Dinoprostone 20mg; per vaginal suppository.

Pharmacological Class

Prostaglandin E2.

How Supplied



Prostin E2 Indications


For the termination of pregnancy from the 12th through the 20th gestational weeks. For the evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age. Management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole).

Prostin E2 Dosage and Administration


Insert one supp high into vagina. Remain in supine position for 10mins following insertion. May insert subsequent supp at 3–5hr intervals until abortion occurs. Continuous administration for more than 2 days is not recommended.


Not established.

Prostin E2 Contraindications


Acute pelvic inflammatory disease. Active cardiac, pulmonary, renal or hepatic disease.

Prostin E2 Boxed Warnings

Boxed Warning

Only use with strict adherence to recommended dosages. Should only be used by medically trained personnel in a hospital setting.

Prostin E2 Warnings/Precautions


Not indicated if fetus in utero has reached the stage of viability. Not for use in cervical ripening or other indication in patients with term pregnancy. Asthma. Hypo-or hypertension. Anemia. Jaundice. Diabetes. Epilepsy. History of cardiac, renal, or hepatic disease. Cervicitis. Infected endocervical lesions. Acute vaginitis. Compromised (scarred) uteri. Remove supp if hypersensitivity reaction is suspected. Pregnancy.

Prostin E2 Pharmacokinetics

See Literature

Prostin E2 Interactions


Concomitant other oxytocic agents: not recommended.

Prostin E2 Adverse Reactions

Adverse Reactions

Vomiting, transient pyrexia (see full labeling re: PGEs induced pyrexia vs. endometritis pyrexia), diarrhea, nausea, headache, chills, transient decrease in BP; MI in patients with history of CVD, hypersensitivity.

Prostin E2 Clinical Trials

See Literature

Prostin E2 Note

Not Applicable

Prostin E2 Patient Counseling

See Literature