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Propranolol Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 10mg, 20mg, 40mg, 60mg, 80mg; scored tabs.
Pharmacological Class
Beta-blocker.
See Also
How Supplied
Tabs—contact supplier; LA—100
Manufacturer
Mechanism of Action
Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. Propranolol generally reduces the oxygen requirement of the heart at any given level of effort by blocking the catecholamine-induced increases in the heart rate, systolic blood pressure, and the velocity and extent of myocardial contraction.
Propranolol Indications
Indications
Long-term management of angina. Hypertrophic subaortic stenosis.
Propranolol Dosage and Administration
Adult
Angina: 80–320mg/day divided into 2, 3, or 4 doses. Stenosis: 20–40mg 3–4 times a day before meals and at bedtime.
Children
Not recommended.
Propranolol Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Propranolol Boxed Warnings
Not Applicable
Propranolol Warnings/Precautions
Warnings/Precautions
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Propranolol Pharmacokinetics
Elimination
Renal. Half-life: 3–6hrs.
Propranolol Interactions
Interactions
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Propranolol Adverse Reactions
Adverse Reactions
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Propranolol Clinical Trials
See Literature
Propranolol Note
Not Applicable
Propranolol Patient Counseling
See Literature
Propranolol Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 10mg, 20mg, 40mg, 60mg, 80mg; scored tabs.
Pharmacological Class
Beta-blocker.
See Also
How Supplied
Tabs 60mg—100; 10mg, 20mg, 40mg, 80mg—100, 5000
Manufacturer
Mechanism of Action
Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. It exerts its antiarrhythmic effects in concentrations associated with β-adrenergic blockade.
Propranolol Indications
Indications
Atrial and ventricular arrhythmias (see literature). Tachyarrhythmia due to digitalis intoxication. In stabilized patients after MI, to reduce mortality and risk of reinfarction.
Propranolol Dosage and Administration
Adult
Arrhythmias: 10–30mg 3–4 times a day before meals and at bedtime. Post-MI: 180–240mg daily in divided doses.
Children
Not recommended.
Propranolol Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Propranolol Boxed Warnings
Not Applicable
Propranolol Warnings/Precautions
Warnings/Precautions
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Propranolol Pharmacokinetics
Elimination
Renal. Half-life: 3–6hrs.
Propranolol Interactions
Interactions
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Propranolol Adverse Reactions
Adverse Reactions
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Propranolol Clinical Trials
See Literature
Propranolol Note
Not Applicable
Propranolol Patient Counseling
See Literature
Propranolol Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 10mg, 20mg, 40mg, 60mg, 80mg; scored tabs.
Pharmacological Class
Beta-blocker.
See Also
How Supplied
Tabs—contact supplier; LA—100
Manufacturer
Mechanism of Action
Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. Its antihypertensive effect is thought to include: decreased cardiac output, inhibition of renin release by the kidneys, and diminution of tonic sympathetic nerve outflow from vasomotor centers in the brain.
Propranolol Indications
Indications
Hypertension. Adjunct in pheochromocytoma.
Propranolol Dosage and Administration
Adult
Initially 40mg twice a day. Usual maintenance: 120–240mg daily; max 640mg daily. Pheochromocytoma: 60mg daily in divided doses for 3 days pre-op or 30mg daily in inoperable cases.
Children
Initially 1mg/kg daily. Usual range: 2–4mg/kg per day in 2 divided doses; max 16mg/kg per day.
Propranolol Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Propranolol Boxed Warnings
Not Applicable
Propranolol Warnings/Precautions
Warnings/Precautions
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Propranolol Pharmacokinetics
Elimination
Renal. Half-life: 3–6hrs.
Propranolol Interactions
Interactions
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Propranolol Adverse Reactions
Adverse Reactions
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Propranolol Clinical Trials
See Literature
Propranolol Note
Not Applicable
Propranolol Patient Counseling
See Literature
Propranolol Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl 10mg, 20mg, 40mg, 60mg, 80mg; scored tabs.
Pharmacological Class
Beta-blocker.
See Also
How Supplied
Tabs—contact supplier; LA—100
Manufacturer
Mechanism of Action
Propranolol, a nonselective β-adrenergic receptor blocker, does not possess autonomic nervous system activity. The mechanism of the antimigraine effect has not been established. β-adrenergic receptors have been demonstrated in the pial vessels of the brain.
Propranolol Indications
Indications
Migraine prophylaxis.
Propranolol Dosage and Administration
Adult
Initially 80mg daily in divided doses. Usual range: 160–240mg daily. Discontinue if poor result after 4–6 weeks.
Children
Not recommended.
Propranolol Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. Overt heart failure. Cardiogenic shock.
Propranolol Boxed Warnings
Not Applicable
Propranolol Warnings/Precautions
Warnings/Precautions
CHF. Wolff-Parkinson-White syndrome. Renal or hepatic dysfunction. Bronchospastic disease, COPD. Diabetes. Hyperthyroidism. Surgery. SLE. Avoid abrupt cessation. Elderly. Pregnancy (Cat.C). Nursing mothers.
Propranolol Pharmacokinetics
Elimination
Renal. Half-life: 3–6hrs.
Propranolol Interactions
Interactions
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. May increase cardiac effects of calcium channel blockers, digitalis, lidocaine. Potentiates theophylline, antipyrine, lidocaine. May block epinephrine. May interfere with glaucoma screening tests.
Propranolol Adverse Reactions
Adverse Reactions
Heart failure, hypotension, bronchospasm, bradycardia, heart block, fatigue, dizziness, depression, GI upset, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), pharyngitis, agranulocytosis.
Propranolol Clinical Trials
See Literature
Propranolol Note
Not Applicable
Propranolol Patient Counseling
See Literature
