Propranolol/hydrochlorothiazide

— THERAPEUTIC CATEGORIES —
  • Hypertension

Propranolol/hydrochlorothiazide Generic Name & Formulations

General Description

Propranolol HCl, hydrochlorothiazide; 40mg/25mg, 80mg/25mg; scored tabs.

Pharmacological Class

Noncardioselective beta-blocker + diuretic.

How Supplied

Contact supplier

Propranolol/hydrochlorothiazide Indications

Indications

Hypertension.

Propranolol/hydrochlorothiazide Dosage and Administration

Adult

Titrate individual components. Max 50mg/day HCTZ.

Children

Not established.

Propranolol/hydrochlorothiazide Contraindications

Contraindications

Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. CHF. Cardiogenic shock. Anuria. Sulfonamide allergy.

Propranolol/hydrochlorothiazide Boxed Warnings

Not Applicable

Propranolol/hydrochlorothiazide Warnings/Precautions

Warnings/Precautions

Overt heart failure. Ischemic heart disease. Wolff-Parkinson-White syndrome. Bronchospasm, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Monitor electrolytes. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Propranolol/hydrochlorothiazide Pharmacokinetics

See Literature

Propranolol/hydrochlorothiazide Interactions

Interactions

Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. Potentiates antipyrine, lidocaine, nondepolarizing muscle relaxants, theophylline. Adjust antidiabetic medication. May increase cardiac effects of calcium channel blockers, lidocaine, diazoxide, digitalis, lithium. Amphotericin B, ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid, glaucoma screening tests. May block epinephrine.

Propranolol/hydrochlorothiazide Adverse Reactions

Adverse Reactions

Heart failure, bronchospasm, bradycardia, heart block, fatigue, fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, orthostatic hypotension, dizziness, GI upset, depression, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), photosensitivity, pharyngitis, agranulocytosis.

Propranolol/hydrochlorothiazide Clinical Trials

See Literature

Propranolol/hydrochlorothiazide Note

Notes

Formerly known under the brand name Inderide.

Propranolol/hydrochlorothiazide Patient Counseling

See Literature