• Hypertension

Propranolol/hydrochlorothiazide Generic Name & Formulations

General Description

Propranolol HCl, hydrochlorothiazide; 40mg/25mg, 80mg/25mg; scored tabs.

Pharmacological Class

Noncardioselective beta-blocker + diuretic.

How Supplied

Contact supplier

Propranolol/hydrochlorothiazide Indications



Propranolol/hydrochlorothiazide Dosage and Administration


Titrate individual components. Max 50mg/day HCTZ.


Not established.

Propranolol/hydrochlorothiazide Contraindications


Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. CHF. Cardiogenic shock. Anuria. Sulfonamide allergy.

Propranolol/hydrochlorothiazide Boxed Warnings

Not Applicable

Propranolol/hydrochlorothiazide Warnings/Precautions


Overt heart failure. Ischemic heart disease. Wolff-Parkinson-White syndrome. Bronchospasm, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Monitor electrolytes. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.

Propranolol/hydrochlorothiazide Pharmacokinetics

See Literature

Propranolol/hydrochlorothiazide Interactions


Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. Potentiates antipyrine, lidocaine, nondepolarizing muscle relaxants, theophylline. Adjust antidiabetic medication. May increase cardiac effects of calcium channel blockers, lidocaine, diazoxide, digitalis, lithium. Amphotericin B, ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid, glaucoma screening tests. May block epinephrine.

Propranolol/hydrochlorothiazide Adverse Reactions

Adverse Reactions

Heart failure, bronchospasm, bradycardia, heart block, fatigue, fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, orthostatic hypotension, dizziness, GI upset, depression, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), photosensitivity, pharyngitis, agranulocytosis.

Propranolol/hydrochlorothiazide Clinical Trials

See Literature

Propranolol/hydrochlorothiazide Note


Formerly known under the brand name Inderide.

Propranolol/hydrochlorothiazide Patient Counseling

See Literature