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Propranolol/hydrochlorothiazide Generic Name & Formulations
Legal Class
Rx
General Description
Propranolol HCl, hydrochlorothiazide; 40mg/25mg, 80mg/25mg; scored tabs.
Pharmacological Class
Noncardioselective beta-blocker + diuretic.
How Supplied
Contact supplier
Manufacturer
Propranolol/hydrochlorothiazide Indications
Indications
Hypertension.
Propranolol/hydrochlorothiazide Dosage and Administration
Adult
Titrate individual components. Max 50mg/day HCTZ.
Children
Not established.
Propranolol/hydrochlorothiazide Contraindications
Contraindications
Asthma. Sinus bradycardia. 2nd- or 3rd-degree AV block. CHF. Cardiogenic shock. Anuria. Sulfonamide allergy.
Propranolol/hydrochlorothiazide Boxed Warnings
Not Applicable
Propranolol/hydrochlorothiazide Warnings/Precautions
Warnings/Precautions
Overt heart failure. Ischemic heart disease. Wolff-Parkinson-White syndrome. Bronchospasm, COPD. Renal or hepatic dysfunction. Gout. Diabetes. Postsympathectomy. Hyperthyroidism. Monitor electrolytes. Surgery. SLE. Avoid abrupt cessation. Pregnancy (Cat.C). Nursing mothers: not recommended.
Propranolol/hydrochlorothiazide Pharmacokinetics
See Literature
Propranolol/hydrochlorothiazide Interactions
Interactions
Potentiated by alcohol, CNS depressants, other antihypertensives, antithyroid drugs, haloperidol, chlorpromazine, cimetidine. Bradycardia with catecholamine-depleting drugs. Antagonized by NSAIDs, barbiturates, rifampin, phenytoin. Potentiates antipyrine, lidocaine, nondepolarizing muscle relaxants, theophylline. Adjust antidiabetic medication. May increase cardiac effects of calcium channel blockers, lidocaine, diazoxide, digitalis, lithium. Amphotericin B, ACTH, corticosteroids increase hypokalemia risk. May interfere with parathyroid, glaucoma screening tests. May block epinephrine.
Propranolol/hydrochlorothiazide Adverse Reactions
Adverse Reactions
Heart failure, bronchospasm, bradycardia, heart block, fatigue, fluid or electrolyte imbalance, hyperglycemia, hyperuricemia, orthostatic hypotension, dizziness, GI upset, depression, skin reactions (eg, rash, Stevens-Johnson syndrome, urticaria), photosensitivity, pharyngitis, agranulocytosis.
Propranolol/hydrochlorothiazide Clinical Trials
See Literature
Propranolol/hydrochlorothiazide Note
Notes
Formerly known under the brand name Inderide.
Propranolol/hydrochlorothiazide Patient Counseling
See Literature
