Propantheline Bromide

  • Hyperacidity, GERD, and ulcers

Propantheline Bromide Generic Name & Formulations

General Description

Propantheline bromide 15mg; tabs.

Pharmacological Class


How Supplied


Propantheline Bromide Indications


Adjunctive therapy in the treatment of peptic ulcer.

Propantheline Bromide Dosage and Administration


15mg taken 30mins before each meal and 30mg at bedtime. Total daily dose: 75mg.


Not recommended.

Propantheline Bromide Contraindications


Glaucoma. GI obstruction (eg, pyloroduodenal stenosis, achalasia, paralytic ileus). GU obstruction (eg, bladder-neck obstruction due to prostatic hypertrophy). Intestinal atony of elderly or debilitated. Severe ulcerative colitis. Toxic megacolon. Unstable cardiovascular adjustment in acute hemorrhage. Myasthenia gravis.

Propantheline Bromide Boxed Warnings

Not Applicable

Propantheline Bromide Warnings/Precautions


High environmental temperature. Monitor for diarrhea; may be symptom of incomplete intestinal obstruction. Heart disease. CHF. Cardiac tachyarrhythmias. Hypertension. Hiatal hernia associated with reflux esophagitis. Autonomic neuropathy. Hepatic or renal disease. Hyperthyroidism. Elderly. Pregnancy (Cat.C). Nursing mothers.

Propantheline Bromide Pharmacokinetics

See Literature

Propantheline Bromide Interactions


Additive anticholinergic effects with concomitant belladonna alkaloids, narcotic analgesics (eg, meperidine), Class I antiarrhythmics (eg, disopyramide, procainamide, quinidine), antihistamines, phenothiazines (may potentiated sedative effects), tricyclic antidepressants, other anticholinergics. Increased intraocular pressure with concomitant corticosteroids. May potentiate slow-dissolving digoxin tablets; use rapidly-dissolving digoxin tablets instead.

Propantheline Bromide Adverse Reactions

Adverse Reactions

Drying of salivary secretions, decreased sweating, ophthalmic effects (eg, blurred vision, mydriasis, cycloplegia, increased ocular tension), urinary hesitancy and retention, tachycardia, palpitations, loss of sense of taste, headache, nervousness, mental confusion, drowsiness, weakness, dizziness, insomnia, GI upset, constipation, bloating, impotence, lactation suppression, allergic reactions.

Propantheline Bromide Clinical Trials

See Literature

Propantheline Bromide Note


Formerly known under the brand name Pro-Banthine.

Propantheline Bromide Patient Counseling

See Literature