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Promethazine Dm Generic Name & Formulations
Legal Class
Rx
General Description
Promethazine HCl 6.25mg, dextromethorphan HBr 15mg; per 5mL; liq; contains alcohol 7%.
Pharmacological Class
Antihistamine + antitussive.
How Supplied
Contact supplier.
Manufacturer
Promethazine Dm Indications
Indications
Cough and upper respiratory symptoms associated with allergy and common cold.
Promethazine Dm Dosage and Administration
Adult
5mL every 4–6hrs; max 30mL/24hrs.
Children
<2yrs: not recommended. 2–6yrs: 1.25–2.5mL every 4–6hrs; max 10mL/24hrs. 6–12yrs: 2.5–5mL every 4–6hrs; max 20mL/24hrs.
Promethazine Dm Contraindications
Contraindications
Concomitant MAOIs. Comatose states. Lower respiratory tract symptoms. Asthma.
Promethazine Dm Boxed Warnings
Not Applicable
Promethazine Dm Warnings/Precautions
Warnings/Precautions
Children <2yrs: potential for fatal respiratory depression. Atopic children. Compromised respiratory function (eg, COPD, apnea), signs/symptoms of Reye's syndrome or hepatic disease in children: avoid. Seizure disorder. Bone-marrow depression. Narrow-angle glaucoma. GI or GU obstruction. Peptic ulcer. Cardiovascular disease. Hepatic impairment. Debilitated. Elderly. Sedated patients or those confined to supine position. Avoid prolonged sun exposure. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.
Promethazine Dm Pharmacokinetics
See Literature
Promethazine Dm Interactions
Interactions
See Contraindications. Increased extrapyramidal effects with MAOIs. Concomitant epinephrine: not recommended. Increased CNS depression with concomitant CNS depressants (eg, alcohol, sedatives/hypnotics, narcotics, general anesthesia, tricyclics); may need to reduce dose. Caution with other anticholinergics. May get false pregnancy test results.
Promethazine Dm Adverse Reactions
Adverse Reactions
Drowsiness, dizziness, confusion, sedation, insomnia, convulsive seizures, hallucinations, hyperexcitability, GI upset, respiratory depression, cardiovascular effects; possible neuroleptic malignant syndrome, cholestatic jaundice, blood dyscrasias.
Promethazine Dm Clinical Trials
See Literature
Promethazine Dm Note
Not Applicable
Promethazine Dm Patient Counseling
See Literature
