Promethazine Dm

  • Cough and cold

Promethazine Dm Generic Name & Formulations

General Description

Promethazine HCl 6.25mg, dextromethorphan HBr 15mg; per 5mL; liq; contains alcohol 7%.

Pharmacological Class

Antihistamine + antitussive.

How Supplied

Contact supplier.

Promethazine Dm Indications


Cough and upper respiratory symptoms associated with allergy and common cold.

Promethazine Dm Dosage and Administration


5mL every 4–6hrs; max 30mL/24hrs.


<2yrs: not recommended. 2–6yrs: 1.25–2.5mL every 4–6hrs; max 10mL/24hrs. 6–12yrs: 2.5–5mL every 4–6hrs; max 20mL/24hrs.

Promethazine Dm Contraindications


Concomitant MAOIs. Comatose states. Lower respiratory tract symptoms. Asthma.

Promethazine Dm Boxed Warnings

Not Applicable

Promethazine Dm Warnings/Precautions


Children <2yrs: potential for fatal respiratory depression. Atopic children. Compromised respiratory function (eg, COPD, apnea), signs/symptoms of Reye's syndrome or hepatic disease in children: avoid. Seizure disorder. Bone-marrow depression. Narrow-angle glaucoma. GI or GU obstruction. Peptic ulcer. Cardiovascular disease. Hepatic impairment. Debilitated. Elderly. Sedated patients or those confined to supine position. Avoid prolonged sun exposure. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Promethazine Dm Pharmacokinetics

See Literature

Promethazine Dm Interactions


See Contraindications. Increased extrapyramidal effects with MAOIs. Concomitant epinephrine: not recommended. Increased CNS depression with concomitant CNS depressants (eg, alcohol, sedatives/hypnotics, narcotics, general anesthesia, tricyclics); may need to reduce dose. Caution with other anticholinergics. May get false pregnancy test results.

Promethazine Dm Adverse Reactions

Adverse Reactions

Drowsiness, dizziness, confusion, sedation, insomnia, convulsive seizures, hallucinations, hyperexcitability, GI upset, respiratory depression, cardiovascular effects; possible neuroleptic malignant syndrome, cholestatic jaundice, blood dyscrasias.

Promethazine Dm Clinical Trials

See Literature

Promethazine Dm Note

Not Applicable

Promethazine Dm Patient Counseling

See Literature