Prochlorperazine Suppositories

  • Nausea

Prochlorperazine Suppositories Generic Name & Formulations

General Description

Prochlorperazine 25mg.

Pharmacological Class

Piperazine phenothiazine.

See Also

How Supplied

Contact supplier.

Prochlorperazine Suppositories Indications


Severe nausea and vomiting.

Prochlorperazine Suppositories Dosage and Administration


Oral: 5–10mg 3–4 times daily; usual max 40mg/day. Rectal: 25mg twice daily.


<2yrs or <20lbs: not recommended. Oral: 20–29lbs: 2½mg once or twice daily; max 7.5mg/day. 30–39lbs: 2½mg 2–3 times daily; max 10mg/day. 40–85lbs: 2½mg 3 times daily or 5mg twice daily; max 15mg/day.

Prochlorperazine Suppositories Contraindications


Coma. CNS depression. Pediatric surgery. Children <2yrs or <20lbs.

Prochlorperazine Suppositories Boxed Warnings

Not Applicable

Prochlorperazine Suppositories Warnings/Precautions


Discontinue 48 hrs before to 24 hrs after myelography. Cardiovascular disease. Epilepsy. Bone marrow depression. Reye's syndrome. Glaucoma. History of breast cancer. Exposure to extreme heat. Monitor blood, liver, and ocular function. Write ℞ using fractions rather than decimals. Children with acute illness or dehydration. Debilitated. Elderly. Pregnancy, nursing mothers: not recommended.

Prochlorperazine Suppositories Pharmacokinetics

See Literature

Prochlorperazine Suppositories Interactions


Potentiates CNS depression with alcohol, other CNS depressants. Potentiates α-blockers. Levels of both drugs increased with propranolol. May potentiate phenytoin; monitor for toxicity. Adjust anticonvulsant doses. May antagonize oral anticoagulants. Hypotension potentiated with thiazide diuretics. Antagonized by anticholinergics. Decreases guanethidine effects. Monitor for neurologic toxicity with lithium; discontinue if occurs. May cause false (+) PKU test.

Prochlorperazine Suppositories Adverse Reactions

Adverse Reactions

Drowsiness, dizziness, amenorrhea, blurred vision, other anticholinergic effects, skin reactions, hypotension, cholestatic jaundice, photosensitivity, leukopenia, agranulocytosis, neuroleptic malignant syndrome, agitation, insomnia, dystonias, extrapyramidal reactions, pseudoparkinsonism, tardive dyskinesia, may mask emetic signs of disease, lowered seizure threshold, EKG changes, aspiration, deep sleep, hyperprolactinemia, paradoxical excitement in children.

Prochlorperazine Suppositories Clinical Trials

See Literature

Prochlorperazine Suppositories Note


Formerly known under the brand name Compazine.

Prochlorperazine Suppositories Patient Counseling

See Literature