Probenecid + Colchicine

  • Gout

Probenecid + Colchicine Generic Name & Formulations

General Description

Probenecid 500mg, colchicine 0.5mg; scored tabs.

Pharmacological Class

Uricosuric + antiinflammatory.

How Supplied

Contact supplier.

Probenecid + Colchicine Indications


Chronic gouty arthritis.

Probenecid + Colchicine Dosage and Administration


1 tab daily for 1 week, then 1 tab twice daily thereafter. Renal impairment, dose adjustments: see literature.


Not recommended.

Probenecid + Colchicine Contraindications


Acute gouty attack. Blood dyscrasias. Uric acid kidney stones. Children <2 yrs of age. Pregnancy. Concomitant salicylates (antagonizes uricosuric effect).

Probenecid + Colchicine Boxed Warnings

Not Applicable

Probenecid + Colchicine Warnings/Precautions


History of peptic ulcer. Spastic colon. GI, renal, hepatic, or hematological disorders. G6PD deficiency. Monitor blood counts in long-term therapy. Maintain adequate hydration. Alkalization of urine may be required. Debilitated. Elderly. Nursing mothers.

Probenecid + Colchicine Pharmacokinetics

See Literature

Probenecid + Colchicine Interactions


Affects renal clearance of many drugs (esp. penicillins). Potentiates methotrexate (monitor and reduce methotrexate dose). May potentiate thiopental, ketamine, NSAIDs, oral sulfonylureas, acetaminophen, lorazepam, rifampin, other sulfonamides. Pyrazinamide antagonizes uricosuric effect. May cause falsely high readings of theophylline levels, or false (+) RBC or hemoglobin in urine.

Probenecid + Colchicine Adverse Reactions

Adverse Reactions

Headache, dizziness, GI upset, diarrhea, urinary frequency, sore gums, uric acid kidney stones, dermatitis, hematuria, renal colic, fever, peripheral neuritis, myopathy, anemia, blood dyscrasias, hemolytic anemia, purpura, bone marrow depression; rare: severe allergic reactions, anaphylaxis.

Probenecid + Colchicine Clinical Trials

See Literature

Probenecid + Colchicine Note


Formerly known under the brand name Colbenemid.

Probenecid + Colchicine Patient Counseling

See Literature