• Mood disorders

Pristiq Generic Name & Formulations

General Description

Desvenlafaxine (as succinate) 25mg, 50mg, 100mg; ext-rel tabs.

Pharmacological Class


How Supplied

Tabs 25mg—30; 50mg, 100mg—14, 30, 90


Generic Availability


Pristiq Indications


Major depressive disorder.

Pristiq Dosage and Administration


Swallow whole. 50mg once daily. Moderate renal impairment (CrCl 30–50mL/min): max 50mg/day. Severe renal impairment (CrCl <30mL/min), ESRD: max 25mg daily or 50mg every other day. Do not give supplemental dose after dialysis. Moderate to severe hepatic impairment: max 100mg/day. Withdraw gradually.


Not established.

Pristiq Contraindications


During or within 14 days of MAOIs; do not start an MAOI during or within 7 days of desvenlafaxine. Concomitant linezolid or IV methylene blue.

Pristiq Boxed Warnings

Boxed Warning

Suicidal thoughts and behaviors.

Pristiq Warnings/Precautions


Increased risk of suicidal thinking or behavior; monitor for clinical worsening or unusual changes. Screen for bipolar disorder. Monitor for serotonin syndrome; discontinue immediately if occurs. Monitor BP; reduce dose or discontinue if elevated BP persists. Cardio- or cerebrovascular disease. Angle closure glaucoma. Avoid in untreated anatomically narrow angles. History of mania/hypomania. Seizure disorder. Volume depleted. Hyponatremia (esp. in elderly). Sexual dysfunction. Renal or hepatic impairment. Avoid abrupt cessation; monitor. Reevaluate periodically. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (avoid in 3rd trimester); see full labeling for effects on neonate. Nursing mothers.

Pristiq Pharmacokinetics

See Literature

Pristiq Interactions


See Contraindications. Avoid alcohol, concomitant venlafaxine, other forms of desvenlafaxine. Increased risk of serotonin syndrome with other serotonergic drugs (eg, other SNRIs, SSRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs such as linezolid, IV methylene blue). Increased risk of bleeding with concomitant aspirin, NSAIDs, warfarin, or other drugs that affect coagulation; monitor closely. May affect CYP2D6 substrates (eg, desipramine, atomoxetine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine); reduce dose by up to ½ if concomitant with desvenlafaxine 400mg dose. May cause false (+) urine immunoassay screening tests for PCP and amphetamine.

Pristiq Adverse Reactions

Adverse Reactions

Nausea, dizziness, insomnia, hyperhidrosis, constipation, somnolence, decreased appetite, anxiety, specific male sexual dysfunction; rare: interstitial lung disease or eosinophilic pneumonia (consider discontinuing if occurs).

Pristiq Clinical Trials

See Literature

Pristiq Note

Not Applicable

Pristiq Patient Counseling

See Literature