Primaxin Iv 500

— THERAPEUTIC DISORDERS TREATED —
  • Bacterial infections

Primaxin Iv 500 Generic Name & Formulations

General Description

Imipenem 500mg, cilastatin sodium 500mg; pwd for IV infusion after reconstitution and dilution; sodium content 37.5mg (1.6mEq).

Pharmacological Class

Carbapenem (thienamycin) + dehydropeptidase I inhibitor.

How Supplied

Single-dose vials 250mg—contact supplier; 500mg—25

Manufacturer

Primaxin Iv 500 Indications

Indications

Serious susceptible infections including bacterial septicemia, lower respiratory tract, urinary tract, skin and skin structure, bone and joint, intraabdominal, gynecologic, endocarditis.

Primaxin Iv 500 Dosage and Administration

Adult

Base dose on imipenem component. Give by IV infusion only. Infuse over 20–30mins (500mg) or 40–60mins (1000mg); slower rate if nausea/vomiting occurs. Susceptible bacteria: 500mg every 6hrs or 1000mg every 8hrs. Intermediate susceptibility: 1000mg every 6hrs. Max 4g/day. Renal impairment (CrCl <90mL/min): reduce dose; see full labeling. CrCl <15mL/min: not recommended unless hemodialysis starts within 48hrs. Hemodialysis: give after session (see full labeling).

Children

<30kg with renal impairment or CNS infections (seizure risk): not recommended. Base dose on imipenem component. Give by IV infusion only. Infuse over 20–30mins (if ≤500mg) or 40–60mins (if >500mg); slower rate if nausea/vomiting occurs. Non-CNS infections (if ≥1.5kg): <1wk of age: 25mg/kg every 12hrs; 1–4wks: 25mg/kg every 8hrs; 4wks–3mos: 25mg/kg every 6hrs; ≥3mos: 15–25mg/kg every 6hrs. Max 4g/day.

Primaxin Iv 500 Contraindications

Not Applicable

Primaxin Iv 500 Boxed Warnings

Not Applicable

Primaxin Iv 500 Warnings/Precautions

Warnings/Precautions

Not for the treatment of meningitis. Penicillin, cephalosporin, β-lactam, or other allergy. CNS disorders (esp. brain lesions or history of seizures). Monitor renal, hepatic, hematologic function periodically with prolonged use. Renal impairment. Pregnancy. Nursing mothers.

Primaxin Iv 500 Pharmacokinetics

See Literature

Primaxin Iv 500 Interactions

Interactions

Concomitant ganciclovir (increased seizure risk), probenecid: not recommended. May antagonize valproic acid; consider alternative; if co-administration needed, consider supplemental anticonvulsant.

Primaxin Iv 500 Adverse Reactions

Adverse Reactions

Phlebitis, nausea, diarrhea, vomiting, rash, inj site reactions, fever, hypotension, seizures, dizziness, pruritus, vein induration, urticaria, somnolence; C. difficile-associated diarrhea, hypersensitivity reactions (discontinue if occur). Children: also gastroenteritis, discolored urine, oliguria/anuria, oral candidiasis, tachycardia.

Primaxin Iv 500 Clinical Trials

See Literature

Primaxin Iv 500 Note

Not Applicable

Primaxin Iv 500 Patient Counseling

See Literature