• Malaria

Primaquine Generic Name & Formulations

General Description

Primaquine phosphate 26.3mg (equivalent to 15mg base); tabs.

Pharmacological Class


How Supplied



Primaquine Indications


For the radical cure (prevention of relapse) of vivax malaria.

Primaquine Dosage and Administration


1 tab daily for 14 days.


Not recommended.

Primaquine Contraindications


Severe G6PD deficiency. Acutely ill patients suffering from systemic disease manifested by tendency to granulocytopenia (eg, rheumatoid arthritis, SLE). Concomitant hemolytic or bone marrow suppressive drugs, quinacrine. Pregnancy.

Primaquine Boxed Warnings

Not Applicable

Primaquine Warnings/Precautions


Perform G6PD testing prior to initiation. Mild-to-moderate G6PD deficiency or unknown G6PD status: assess risk vs. benefit; if considered, monitor hbg/hct at baseline, at Days 3 and 8 of therapy; have medical support available. Discontinue if signs of hemolytic anemia occur. History of favism. Perform routine CBCs during therapy; in those with history of hemolytic anemia or nicotinamide adenine dinucleotide (NADH) methemoglobin reductase deficiency; monitor closely. Risk for QT prolongation in cardiac disease, long QT syndrome, history of ventricular arrhythmias, uncorrected hypokalemia and/or hypomagnesemia, or bradycardia (<50bpm); monitor ECG. Elderly. Females of reproductive potential should exclude pregnancy prior to initiation and use effective contraception during and after stopping treatment until completion of on-going ovulatory cycle; males should use condoms during and for 3 months after therapy. Nursing mothers: not recommended.

Primaquine Pharmacokinetics

See Literature

Primaquine Interactions


See Contraindications. Caution with concomitant other drugs that prolong the QT interval.

Primaquine Adverse Reactions

Adverse Reactions

Nausea, vomiting, epigastric distress, abdominal cramps, leukopenia, cardiac arrhythmia, dizziness, rash, pruritus.

Primaquine Clinical Trials

See Literature

Primaquine Note

Not Applicable

Primaquine Patient Counseling

See Literature