Prilosec Otc

  • Hyperacidity, GERD, and ulcers

Prilosec Otc Generic Name & Formulations

General Description

Omeprazole (as magnesium) 20mg; delayed-release tabs; regular or wildberry flavor.

Pharmacological Class

Proton pump inhibitor.

How Supplied

Tabs—14, 28, 42

Generic Availability


Prilosec Otc Indications


Frequent heartburn (≥2 days/week). Not intended for immediate relief of heartburn (may take 1–4 days for full effect).

Prilosec Otc Dosage and Administration


Swallow whole. Take before eating in the AM. ≥18yrs: 20mg once daily for 14 days; may repeat 14-day course every 4 months.


<18yrs: not recommended.

Prilosec Otc Contraindications


Trouble or pain swallowing food. Vomiting with blood. Bloody or black stools. Chest or shoulder pain with shortness of breath; sweating; pain spreading to arms, neck, or shoulders; or lightheadedness. Frequent chest pain.

Prilosec Otc Boxed Warnings

Not Applicable

Prilosec Otc Warnings/Precautions


Discontinue if an allergic reaction (eg, rash) occurs. Heartburn >3 months. Frequent wheezing. Unexplained weight loss. Nausea/vomiting. Stomach pain. Discontinue and reevaluate if condition continues or worsens after 14 days, require >1 course of treatment every 4 months; diarrhea or joint pain develops. Pregnancy. Nursing mothers.

Prilosec Otc Pharmacokinetics

See Literature

Prilosec Otc Interactions


May affect or be affected by blood-thinning agents (eg, warfarin, clopidogrel, cilostazol), antifungals, digoxin, diazepam, tacrolimus, mycophenolate mofetil, antiretrovirals, methotrexate.

Prilosec Otc Adverse Reactions

Adverse Reactions

Diarrhea, rash, joint pain; severe skin reactions (eg, skin reddening, blisters).

Prilosec Otc Clinical Trials

See Literature

Prilosec Otc Note

Not Applicable

Prilosec Otc Patient Counseling

See Literature