Prilocaine Hcl

  • Anesthetics

Prilocaine Hcl Generic Name & Formulations

General Description

Prilocaine HCl 40mg/mL; soln for inj.

Pharmacological Class

Local anesthetic (amide-type).

How Supplied

Contact supplier.

Prilocaine Hcl Indications


Local anesthesia in dentistry by nerve block or infiltration techniques.

Prilocaine Hcl Dosage and Administration


Maxillary infiltration: initially 1–2mL; max recommended dose within a 2-hour period: <70kg: 8mg/kg; ≥70kg: 600mg. Elderly, debilitated, acutely ill: reduce dose.


<10yrs: use Clarks rule to calculate dose.

Prilocaine Hcl Contraindications


Congenital or idiopathic methemoglobinemia.

Prilocaine Hcl Boxed Warnings

Not Applicable

Prilocaine Hcl Warnings/Precautions


Have resuscitative equipment, oxygen, and standard protocol for management of malignant hyperthermia available. G6PD deficiency. Severe shock. Heart block. Hepatic disease. Impaired cardiovascular function. Head and neck block. Monitor cardiovascular and respiratory vital signs. Pregnancy (Cat.B). Nursing mothers.

Prilocaine Hcl Pharmacokinetics

See Literature

Prilocaine Hcl Interactions


Risk of methemoglobinemia with sulfonamides, acetaminophen, acetanilid, aniline dyes, benzocaine, chloroquine, dapsone, naphthalene, nitrates and nitrites, nitrofurantoin, nitroglycerin, nitroprusside, pamaquine, para-aminosalicylic acid, phenacetin, phenobarbital, phenytoin, primaquine, quinine.

Prilocaine Hcl Adverse Reactions

Adverse Reactions

Swelling and persistent paresthesia of lips, oral tissue; CNS effects (eg, excitation, depression, restlessness, anxiety, dizziness, tremors), cardiovascular effects (eg, bradycardia, hypotension, cardiovascular collapse), allergic-type reactions, neurologic effects, increased creatinine phosphokinase.

Prilocaine Hcl Clinical Trials

See Literature

Prilocaine Hcl Note


Formerly known under the brand name Citanest Plain Dental.

Prilocaine Hcl Patient Counseling

See Literature