• Nonnarcotic analgesics

Prialt Generic Name & Formulations

General Description

Ziconotide acetate 25mcg/mL, 100mcg/mL; soln for intrathecal infusion; preservative-free.

Pharmacological Class

Analgesic (non-opioid N-type calcium channel blocker).

How Supplied

Soln single-use vial; 25mcg/mL (20mL)—1; 100mcg/mL (1mL, 5mL)—1

Prialt Indications


Management of severe chronic pain in patients for whom intrathecal therapy is warranted and who are intolerant of or refractory to other treatment (eg, systemic analgesics, adjunctive therapies, intrathecal morphine).

Prialt Dosage and Administration


Give by intrathecal infusion using appropriate microinfusion device and procedures. Individualize; see literature. Initial: up to 2.4mcg/day (0.1microgram/hr); titrate in increments of up to 2.4mcg/day (0.1mcg/hr) at intervals of up to 2–3 times per week; max 19.2mcg/day (0.8mcg/hr) by day 21.


Not recommended.

Prialt Contraindications


History of psychosis. Inj site infections. Uncontrolled bleeding diathesis. Spinal canal obstruction.

Prialt Boxed Warnings

Boxed Warning

Neuropsychiatric adverse reactions.

Prialt Warnings/Precautions


Risk of severe psychiatric symptoms and neurological impairment. Monitor for signs/symptoms of meningitis and other infections. Discontinue if infection, cognitive impairment, hallucinations, mood changes, or impaired consciousness occur. Reduce dose or discontinue if myasthenias, myalgia, or persistent increases in serum creatine kinase occur. Hepatic or renal impairment. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.

Prialt Pharmacokinetics

See Literature

Prialt Interactions


Concomitant intrathecal opiates: not recommended. CNS effects potentiated by other CNS depressants, antiepileptics, neuroleptics, diuretics; discontinue ziconotide if occurs.

Prialt Adverse Reactions

Adverse Reactions

Dizziness, GI upset, fever, headache, somnolence, nystagmus, asthenia, ataxia, abnormal vision, dysesthesia, parasthesia, urinary retention, psychiatric effects (eg, hallucinations, mania), cognitive/memory impairment (eg, confusion, aphasia, stupor), worsening depression/suicidal ideation.

Prialt Clinical Trials

See Literature

Prialt Note

Not Applicable

Prialt Patient Counseling

See Literature