• Labor and delivery

Prepidil Generic Name & Formulations

General Description

Dinoprostone 0.5mg/3g; endocervical gel.

Pharmacological Class

PGE2 oxytocic.

How Supplied

Prefilled-syringe applicator (w. catheters)—5


Prepidil Indications


Ripening an unfavorable cervix in pregnant women at or near term.

Prepidil Dosage and Administration


See full labeling.


Not applicable.

Prepidil Contraindications


Where oxytocics or prolonged uterine contractions are inappropriate, including: history of cesarean section, major uterine surgery, presence of cephalopelvic disproportion, difficult labor, traumatic delivery, 6 or more previous term pregnancies, nonvertex presentation, hyperactive or hypertonic uterine patterns, fetal distress where delivery is not imminent. Ruptured membranes. Placenta previa or unexplained vaginal bleeding. When vaginal delivery is not indicated. Concomitant oxytocics.

Prepidil Boxed Warnings

Not Applicable

Prepidil Warnings/Precautions


For hospital use only when immediate intensive care and acute surgical facilities can be provided. Avoid contact with skin. Monitor uterine activity, fetal status, cervix. History of/or asthma. Glaucoma or increased intraocular pressure. If hypersensitivity reaction is suspected, remove Prepidil gel if possible. Renal or hepatic dysfunction. Pregnancy (Cat.C).

Prepidil Pharmacokinetics

See Literature

Prepidil Interactions


Potentiates oxytocics. Oxytocin: a dosing interval of 6–12hrs is needed, if used following Prepidil administration.

Prepidil Adverse Reactions

Adverse Reactions

Maternal: Uterine rupture, uterine contraction abnormality, GI upset, back pain, warm feeling in vagina, fever, premature rupture of membranes. Fetal: Heart rate abnormality, fetal depression, fetal acidosis. Amnionitis and intrauterine fetal sepsis associated with extra-intrauterine administration.

Prepidil Clinical Trials

See Literature

Prepidil Note

Not Applicable

Prepidil Patient Counseling

See Literature