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Prednisone Generic Name & Formulations
Legal Class
Rx
General Description
Prednisone 1mg, 2.5mg, 5mg, 10mg, 20mg, 50mg; scored tabs.
Pharmacological Class
Glucocorticoid.
How Supplied
Contact supplier.
Manufacturer
Prednisone Indications
Indications
Corticosteroid-responsive disorders.
Prednisone Dosage and Administration
Adults and Children
See full labeling. Initially 5–60mg daily.
Prednisone Contraindications
Contraindications
Systemic fungal infections. Live vaccines.
Prednisone Boxed Warnings
Not Applicable
Prednisone Warnings/Precautions
Warnings/Precautions
Tuberculosis. Latent amebiasis. Strongyloides infestation. Hypothyroidism. Ocular herpes simplex. Cirrhosis. Renal insufficiency. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Hypertension. Osteoporosis. Diabetes. Kaposi's sarcoma. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8AM minimize adrenal suppression. Use lowest effective dose. Monitor weight, growth, fluid and electrolyte balance. Pregnancy. Nursing mothers.
Prednisone Pharmacokinetics
See Literature
Prednisone Interactions
Interactions
Barbiturates, hydantoins, rifampin, other hepatic enyzme inducers may decrease effects. Potentiated by ketoconazole, troleandomycin. Excretion of high-dose aspirin increased. Caution with diuretics, digoxin, aspirin in hypoprothrombinemia. Potentiated by oral contraceptives. Monitor oral anticoagulants.
Prednisone Adverse Reactions
Adverse Reactions
HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.
Prednisone Clinical Trials
See Literature
Prednisone Note
Notes
Formerly known under the brand names Deltasone, Meticorten, Orasone, Paracort.
Prednisone Patient Counseling
See Literature
