Prednisone

— THERAPEUTIC DISORDERS TREATED —
  • Corticosteroid-responsive disorders

Prednisone Generic Name & Formulations

General Description

Prednisone 1mg, 2.5mg, 5mg, 10mg, 20mg, 50mg; scored tabs.

Pharmacological Class

Glucocorticoid.

How Supplied

Contact supplier.

Prednisone Indications

Indications

Corticosteroid-responsive disorders.

Prednisone Dosage and Administration

Adults and Children

See full labeling. Initially 5–60mg daily.

Prednisone Contraindications

Contraindications

Systemic fungal infections. Live vaccines.

Prednisone Boxed Warnings

Not Applicable

Prednisone Warnings/Precautions

Warnings/Precautions

Tuberculosis. Latent amebiasis. Strongyloides infestation. Hypothyroidism. Ocular herpes simplex. Cirrhosis. Renal insufficiency. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Hypertension. Osteoporosis. Diabetes. Kaposi's sarcoma. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8AM minimize adrenal suppression. Use lowest effective dose. Monitor weight, growth, fluid and electrolyte balance. Pregnancy. Nursing mothers.

Prednisone Pharmacokinetics

See Literature

Prednisone Interactions

Interactions

Barbiturates, hydantoins, rifampin, other hepatic enyzme inducers may decrease effects. Potentiated by ketoconazole, troleandomycin. Excretion of high-dose aspirin increased. Caution with diuretics, digoxin, aspirin in hypoprothrombinemia. Potentiated by oral contraceptives. Monitor oral anticoagulants.

Prednisone Adverse Reactions

Adverse Reactions

HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.

Prednisone Clinical Trials

See Literature

Prednisone Note

Notes

Formerly known under the brand names Deltasone, Meticorten, Orasone, Paracort.

Prednisone Patient Counseling

See Literature