Prednisone Oral Solution

  • Corticosteroid-responsive disorders

Prednisone Oral Solution Generic Name & Formulations

General Description

Prednisone 5mg; per 5mL; contains alcohol 5%.

Pharmacological Class


How Supplied

Soln—120mL, 500mL; Intensol—30mL (w. dropper)

Prednisone Oral Solution Indications


Corticosteroid-responsive disorders.

Prednisone Oral Solution Dosage and Administration

Adults and Children

See literature. Initially 5mg–60mg daily. Intensol: mix with liquid or semi-solid food.

Prednisone Oral Solution Contraindications


Systemic fungal infections. Live vaccines.

Prednisone Oral Solution Boxed Warnings

Not Applicable

Prednisone Oral Solution Warnings/Precautions


Tuberculosis. Latent amebiasis. Strongyloides infestation. Hypothyroidism. Ocular herpes simplex. Cirrhosis. Renal insufficiency. If exposed to chickenpox or measles, consider prophylactic passive immune therapy. Ulcerative colitis if perforation pending. Peptic ulcer. Diverticulitis. Intestinal anastomoses. Myasthenia gravis. Hypertension. Osteoporosis. Diabetes. Kaposi's sarcoma. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. May increase risk and mask signs of infection. May cause electrolyte imbalances, adrenocortical insufficiency, psychotic derangements. Alternate, intermittent, or single-daily doses at 8AM minimize adrenal suppression. Use lowest effective dose. Monitor weight, growth, fluid and electrolyte balance. Pregnancy. Nursing mothers.

Prednisone Oral Solution Pharmacokinetics

See Literature

Prednisone Oral Solution Interactions


Barbiturates, hydantoins, rifampin, other hepatic enyzme inducers may decrease effects. Potentiated by ketoconazole, troleandomycin. Excretion of high-dose aspirin increased. Caution with diuretics, digoxin, aspirin in hypoprothrombinemia. Potentiated by oral contraceptives. Monitor oral anticoagulants.

Prednisone Oral Solution Adverse Reactions

Adverse Reactions

HPA axis suppression, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, CHF, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.

Prednisone Oral Solution Clinical Trials

See Literature

Prednisone Oral Solution Note

Not Applicable

Prednisone Oral Solution Patient Counseling

See Literature