Pred-g Generic Name & Formulations
Prednisolone acetate 1%, gentamicin (as sulfate) 0.3%; oph. susp; contains benzalkonium chloride.
Steroid + aminoglycoside.
Susp—5mL, 10mL; Oint—3.5g
Mechanism of Action
Corticosteroids suppress the inflammatory response to a variety of agents and they probably delay or slow healing. Since corticosteroids may inhibit the body’s defense mechanism against infection, a concomitant antimicrobial drug may be used when this inhibition is considered to be clinically significant in a particular case.
Ocular inflammation associated with infection.
Pred-g Dosage and Administration
1 drop 2–4 times daily; max 20mL for initial ℞.
Fungal, viral or mycobacterial infections.
Pred-g Boxed Warnings
Not for uncomplicated removal of foreign body. Corneal or scleral thinning. Glaucoma. Monitor for secondary infections, cataracts, and intraocular pressure in prolonged use. May mask signs of infection. Avoid abrupt cessation. Pregnancy. Nursing mothers: not recommended.
Renal. Half-life: 2.1–3.5 hours (prednisolone).
Pred-g Adverse Reactions
In prolonged use increased intraocular pressure, cataracts, corneal perforation, optic nerve damage, secondary infections. Ocular discomfort (eg, burning, stinging, hyperemia, pain, discharge, edema, irritation), visual impairment, blurry vision, foreign body sensation in eyes, dysgeusia, punctate keratitis, delayed wound healing, hypersensitivity or allergic skin reactions.
Pred-g Clinical Trials
Pred-g Patient Counseling