Porcine Secretin Generic Name & Formulations
Porcine secretin 16mcg; per vial; lyophilized pwd for IV inj after reconstitution.
Porcine Secretin Indications
For the stimulation of pancreatic secretions, including bicarbonate to aid in the diagnosis of pancreatic exocrine dysfunction, and to facilitate the identification of the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP). For the stimulation of gastrin secretin to aid in the diagnosis of gastrinoma.
Porcine Secretin Dosage and Administration
See full labeling. Discontinue interacting drugs (eg, anticholinergics, H2-receptor antagonists, or PPIs) prior to testing accordingly; see Interactions. Administer IV test dose (0.2mcg); if no hypersensitivity reaction after 1min, give recommended dose as IV inj slowly over 1min. Exocrine pancreas dysfunction (fast for at least 12–15hrs prior to testing): 0.2mcg/kg. ERCP: 0.2mcg/kg. Gastrinoma (fast for at least 12hrs prior to testing): 0.4mcg/kg.
Porcine Secretin Contraindications
Acute hypersensitivity reaction to test dose. Documented hypersensitivity reaction to porcine products.
Porcine Secretin Boxed Warnings
Porcine Secretin Warnings/Precautions
Stimulation testing should only be performed by physicians with sufficient expertise. Have appropriate resuscitative measures available. History of atopy. Undergone vagotomy, inflammatory bowel disease: may be hyporesponsive to stimulation. Alcoholic or other liver disease: may be hyperresponsive to stimulation. Pregnancy. Nursing mothers.
Porcine Secretin Pharmacokinetics
Porcine Secretin Interactions
Possible hyporesponse to stimulation testing with concomitant anticholinergics; discontinue at least 5 half-lives prior to testing. Possible hyperresponse with concomitant H2-receptor antagonists; discontinue at least 2 days prior to testing. Concomitant PPIs may cause hyperresponse to stimulation: refer to specific labeling prior to testing.
Porcine Secretin Adverse Reactions
Abdominal discomfort, nausea, flushing, burning in stomach, diaphoresis, bradycardia, decreased BP.
Porcine Secretin Clinical Trials
Porcine Secretin Note
Porcine Secretin Patient Counseling