Ponvory Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Ponvory Indications
Indications
Ponvory Dosage and Administration
Adult
Children
Renal Impairment
Hepatic Impairment
Not recommended in patients with moderate or severe hepatic impairment.
Other Modifications
Contraception
-
Females: Advise females of reproductive potential to use effective contraception during and for 1 week after discontinuation.
Ponvory Contraindications
Contraindications
Ponvory Boxed Warnings
Not Applicable
Ponvory Warnings/Precautions
Warnings/Precautions
Ponvory Pharmacokinetics
Absorption
The time to reach maximum plasma concentration of ponesimod is 2-4 hours post-dose. The absolute oral bioavailability of a 10 mg dose is 84%.
Distribution
Following IV administration in healthy subjects, the steady-state volume of distribution of ponesimod is 160 L. Ponesimod is highly bound to plasma proteins (> 99%) and is mainly (78.5%) distributed in the plasma fraction of whole blood. Animal studies show that ponesimod readily crosses the blood-brain-barrier.
Elimination
After a single IV administration, the total clearance of ponesimod is 3.8 L/hour. The elimination half-life after oral administration is approximately 33 hours. Following a single oral administration of 14C-ponesimod, 57% to 80% of the dose was recovered in feces (16% as unchanged ponesimod), and 10% to 18% in urine (no unchanged ponesimod).
Ponvory Interactions
Interactions
Ponvory Adverse Reactions
Adverse Reactions
Ponvory Clinical Trials
Ponvory Note
Not Applicable
Ponvory Patient Counseling
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