Plenvu Generic Name & Formulations
Polyethylene glycol 3350 140g, sodium ascorbate 48.11g, sodium sulfate 9g, ascorbic acid 7.54g, sodium chloride 5.2g, potassium chloride 2.2g; per 32 fluid ounces; pwd for reconstitution; contains phenylalanine 491mg/treatment; mango- or fruit punch-flavor.
Carton—1 (disposable container w. 3 pouches)
Bowel cleansing before colonoscopy.
Plenvu Dosage and Administration
No solid food from start of prep. Two-day regimen: start the evening before colonoscopy, drink 480mL over 30mins, follow with 480mL of clear liquids over next 30mins; in the AM, drink 480mL over 30mins, then drink 480mL of clear liquids over next 30mins. Consume additional water or clear liquids up to 2hrs before colonoscopy. One-day regimen: start the morning of colonoscopy, drink 480mL over 30mins, follow with 480mL of clear liquids over next 30mins. At minimum of 2hrs after first dose, drink 480mL over 30mins, follow with 480mL of clear liquids over next 30mins. Consume additional water or clear liquids up to 2hrs before colonoscopy.
GI obstruction. Bowel perforation. Gastric retention. Ileus. Toxic megacolon.
Plenvu Boxed Warnings
Correct fluid/electrolyte abnormalities before use. History of prolonged QT, uncontrolled arrhythmias, recent MI, unstable angina, CHF, cardiomyopathy, or electrolyte imbalance: increased risk of arrhythmias; consider pre-dose and post-colonoscopy ECGs. History or risk of seizures. Renal impairment; perform baseline and post-colonoscopy electrolytes, creatinine, BUN. Inflammatory bowel disease. Rule out suspected GI obstruction/perforation before administering. Severe ulcerative colitis. Impaired gag reflex or other swallowing abnormalities; risk for regurgitation or aspiration. G6PD deficiency. Phenylketonuria. Maintain adequate hydration. Elderly. Pregnancy. Nursing mothers.
Avoid reconstitution of prep with starch-based thickeners. Caution with drugs that increase risk of fluid/electrolyte abnormalities, renal impairment, seizures, arrhythmias, or QT prolongation. Drugs that may lower the seizure threshold (eg, tricyclic antidepressants), alcohol or benzodiazepine withdrawal, known or suspected hyponatremia: may increase risk of seizures. Concomitant diuretics, ACE inhibitors, ARBs, NSAIDs; may affect renal function. Concomitant stimulant laxatives: not recommended; may increase risk of mucosal ulceration, ischemic colitis. Oral drugs administered within 1hr of start of Plenvu may not be absorbed.
Plenvu Adverse Reactions
Nausea, vomiting, dehydration, abdominal pain/discomfort, fatigue, headache; hypersensitivity reactions; rare: arrhythmias, tonic-clonic seizures.
Plenvu Clinical Trials
Plenvu Patient Counseling