Plegridy Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Plegridy Indications
Indications
Plegridy Dosage and Administration
Adult
Children
Renal Impairment
Monitor for adverse reactions due to increased drug exposure in patients with severe renal impairment.
Plegridy Contraindications
Not Applicable
Plegridy Boxed Warnings
Not Applicable
Plegridy Warnings/Precautions
Warnings/Precautions
Plegridy Pharmacokinetics
Absorption
After 125 microgram subcutaneous doses of Plegridy in multiple sclerosis patients, the maximum concentration occurred between 1 and 1.5 days, the mean Cmax was 280 pg/mL, and the AUC over the 14 day dosing interval was 34.8 ng.hr/mL.
Distribution
In multiple sclerosis patients taking 125 microgram subcutaneous doses of Plegridy every 14 days, the estimated volume of distribution was 481 liters.
Elimination
The major pathway of elimination is renal. The half-life is approximately 78 hours in multiple sclerosis patients.