• Actinic keratoses

Picato Generic Name & Formulations

General Description

Ingenol mebutate 0.015%, 0.05%; topical gel.

Pharmacological Class

Cell death inducer.

How Supplied

Single-use tubes 0.015%—3; 0.05%—2


Picato Indications


Topical treatment of actinic keratosis.

Picato Dosage and Administration


For topical use only; not for oral, ophthalmic, or intravaginal use. Face or scalp: apply 0.015% gel to the affected area once daily for 3 consecutive days. Trunk or extremities: apply 0.05% gel to the affected area once daily for 2 consecutive days. Limit application to one contiguous skin area of approximately 25cm2 using one unit dose tube. Allow treated area to dry for 15 minutes after application. Wash hands immediately after application; avoid inadvertent transfer of drug to other areas (eg, eyes). Avoid washing and touching treated area for 6 hours after application; following this time, may wash with mild soap.


<18yrs: not established.

Picato Contraindications

Not Applicable

Picato Boxed Warnings

Not Applicable

Picato Warnings/Precautions


Avoid in periocular area, near mouth or lips. Eye disorders (eg, severe eye pain, chemical conjunctivitis, corneal burn, eyelid edema, eyelid ptosis, periorbital edema) can occur after exposure. Discontinue if significant hypersensitivity reactions occur. Severe skin reactions. Do not use until skin is healed from previous drug or surgical treatment. Monitor for skin cancer in those with risk factors. Pregnancy. Nursing mothers: avoid accidental transfer to infants.

Picato Pharmacokinetics

See Literature

Picato Interactions

Not Applicable

Picato Adverse Reactions

Adverse Reactions

Local skin reactions (eg, erythema, flaking/scaling, crusting, swelling, vesiculation/pustulation, erosion/ulceration), application site pain/pruritus/irritation/infection, periorbital edema, nasopharyngitis, headache; hypersensitivity reactions, non-melanoma skin cancer.

Picato Clinical Trials

See Literature

Picato Note

Not Applicable

Picato Patient Counseling

See Literature