• Electrolyte disturbances

Phoxillum Generic Name & Formulations

General Description

BK4/2.5 (Ca2+ 2.5mEq/L, HCO3- 32mEq/L, K+ 4mEq/L, Mg2+ 1.5mEq/L, Na+ 140mEq/L, HPO42- 1mmol/L, Cl- 114.5mEq/L); B22K4/0 (HCO3- 22mEq/L, K+ 4mEq/L, Mg2+ 1.5mEq/L, Na+ 140mEq/L, HPO42- 1mmol/L, Cl- 122mEq/L); soln for IV inf after reconstitution.

Pharmacological Class

Fluid & electrolyte replacement.

How Supplied

2-compartment bag (5000mL)—1


Generic Availability


Phoxillum Indications


Replacement solution for patients on continuous renal replacement therapy (CRRT), to replace plasma volume removed by ultrafiltration and correct electrolyte and acid-base imbalances. To remove dialyzable toxins associated with drug poisoning treated by CRRT.

Phoxillum Dosage and Administration

Adults and Children

Administer only under the direction of a physician trained in intensive care treatment including CRRT: see full labeling. Individualize; determine mode of therapy, solute formulation, flow rates, and duration based on patient’s clinical condition and electrolyte, acid-base, and glucose balances. Administer into extracorporeal circuit before (pre-dilution) and/or after (post-dilution) the hemofilter or hemodiafilter.

Phoxillum Contraindications

Not Applicable

Phoxillum Boxed Warnings

Not Applicable

Phoxillum Warnings/Precautions


Use aseptic technique. Monitor fluid, hemodynamic, electrolyte, and acid-base imbalances; correct as needed. Increased risk of metabolic acidosis. Monitor blood glucose levels; initiate or modify antidiabetic therapy as needed. Pregnancy, nursing mothers: monitor.

Phoxillum Pharmacokinetics

See Literature

Phoxillum Interactions


May antagonize dialyzable drugs: monitor. Concomitant citrate (as anticoagulant) may reduce plasma calcium; select appropriate Phoxillum formulation. May add drugs to bag via injection connector; administer non-phosphate drugs through different access line.

Phoxillum Adverse Reactions

Adverse Reactions

Metabolic acidosis, hypotension, acid-base disorders, electrolyte and fluid imbalance.

Phoxillum Clinical Trials

See Literature

Phoxillum Note

Not Applicable

Phoxillum Patient Counseling

See Literature