Miscellaneous ocular agents:

Indications for: PHOTREXA

For use in corneal collagen cross-linking with the KXL System: to treat progressive keratoconus or corneal ectasia following refractive surgery.

Adult Dosage:

Debride epithelium to approx. 9mm diameter using standard aseptic technique: see full labeling. ≥14yrs: Instill 1 drop (Photrexa Viscous) every 2mins for 30mins; examine eye (under slit lamp) for yellow flare in the anterior chamber. If the yellow flare is not detected, instill 1 drop (Photrexa Viscous) every 2mins for another 2–3 drops and recheck; repeat as necessary. If detected, perform ultrasound pachymetry. If corneal thickness <400microns: instill 2 drops (Photrexa) every 5–10secs until it increases to ≥400microns. For use during eye irradiation, see full labeling.

Children Dosage:

<14yrs: not established.

PHOTREXA Warnings/Precautions:

Must use with the KXL System only. Not for injection. Ulcerative keratitis; monitor for resolution of epithelial defects. Advise patients not to rub eyes for first 5 days after procedure. Monitor for severe eye pain or sudden decrease in vision. Pregnancy: not recommended. Nursing mothers.

See Also:

PHOTREXA Classification:


Adverse Reactions:

Corneal opacity (haze), punctate keratitis, corneal striae, corneal epithelium defect, eye pain, reduced visual acuity, blurred vision, dry eye, photophobia.

Generic Drug Availability:


How Supplied:

Single-use foil pouch—1, 10; Cross-linking Kit—1 (Photrexa + Photrexa Viscous)