• Miscellaneous ocular agents

Photrexa Generic Name & Formulations

General Description

Riboflavin 5'-phosphate 0.146%; oph soln.

Pharmacological Class


See Also

How Supplied

Single-use foil pouch—1, 10; Cross-linking Kit—1 (Photrexa + Photrexa Viscous)


Generic Availability


Photrexa Indications


For use in corneal collagen cross-linking with the KXL System: to treat progressive keratoconus or corneal ectasia following refractive surgery.

Photrexa Dosage and Administration


Debride epithelium to approx. 9mm diameter using standard aseptic technique: see full labeling. ≥14yrs: Instill 1 drop (Photrexa Viscous) every 2mins for 30mins; examine eye (under slit lamp) for yellow flare in the anterior chamber. If the yellow flare is not detected, instill 1 drop (Photrexa Viscous) every 2mins for another 2–3 drops and recheck; repeat as necessary. If detected, perform ultrasound pachymetry. If corneal thickness <400microns: instill 2 drops (Photrexa) every 5–10secs until it increases to ≥400microns. For use during eye irradiation, see full labeling.


<14yrs: not established.

Photrexa Contraindications

Not Applicable

Photrexa Boxed Warnings

Not Applicable

Photrexa Warnings/Precautions


Must use with the KXL System only. Not for injection. Ulcerative keratitis; monitor for resolution of epithelial defects. Advise patients not to rub eyes for first 5 days after procedure. Monitor for severe eye pain or sudden decrease in vision. Pregnancy: not recommended. Nursing mothers.

Photrexa Pharmacokinetics

See Literature

Photrexa Interactions

Not Applicable

Photrexa Adverse Reactions

Adverse Reactions

Corneal opacity (haze), punctate keratitis, corneal striae, corneal epithelium defect, eye pain, reduced visual acuity, blurred vision, dry eye, photophobia.

Photrexa Clinical Trials

See Literature

Photrexa Note

Not Applicable

Photrexa Patient Counseling

See Literature