• Digestive and biliary disorders

Pertzye Generic Name & Formulations

General Description

Lipase/protease/amylase: 4000Units/14375Units/15125Units, 8000Units/28750Units/30250Units, 16000Units/57500Units/60500Units, 24000Units/86250Units/90750Units; del-rel caps.

Pharmacological Class

Pancreatic enzymes (porcine).

How Supplied

Caps 4000 lipase units—100; 8000, 16000 lipase units—100, 250


Generic Availability


Pertzye Indications


Treatment of exocrine pancreatic insufficiency due to cystic fibrosis or other conditions.

Pertzye Dosage and Administration

Adults and Children

Start at the lowest recommended dose and increase gradually. Individualize based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet. Swallow whole; do not crush or chew caps. May mix contents with applesauce or other acidic soft food (pH≤ 4.5); swallow mixture immediately, follow with water or juice; take with meals; do not let any drug remain in mouth. Also, may give via gastrostomy tube; up to max contents of two 4000unit caps at a time. ≤12mos: 4000 lipase units per 120mL of formula or breastmilk; give prior to each feeding, do not mix directly. >12mos–<4yrs: initially 1000 lipase units/kg per meal. ≥4yrs: initially 500 lipase units/kg per meal. Max (>12mos): 2500 lipase units/kg per meal (or ≤10000 lipase units/kg/day), or <4000 lipase units/g fat ingested per day. See full labeling.

Pertzye Contraindications

Not Applicable

Pertzye Boxed Warnings

Not Applicable

Pertzye Warnings/Precautions


Not interchangeable with other pancrelipase products. Fibrosing colonopathy (with high doses); risk of stricture formation (monitor). Pork allergy. Potential viral transmission. Gout. Renal impairment. Hyperuricemia; consider monitoring uric acid levels. Contents irritating to oral mucosa. Pregnancy (Cat.C). Nursing mothers.

Pertzye Pharmacokinetics

See Literature

Pertzye Interactions

Not Applicable

Pertzye Adverse Reactions

Adverse Reactions

Diarrhea, dyspepsia, cough; allergic reactions.

Pertzye Clinical Trials

See Literature

Pertzye Note

Not Applicable

Pertzye Patient Counseling

See Literature