• Periodontal disease

Periostat Generic Name & Formulations

General Description

Doxycycline hyclate 20mg; tabs.

Pharmacological Class

Tetracycline antibiotic.

How Supplied

Tabs—60, 100

Periostat Indications


As an adjunct to scaling and root planing to promote attachment level gain and to reduce pocket depth in patients with adult periodontitis.

Periostat Dosage and Administration


Take on an empty stomach with adequate amount of fluid. 20mg twice daily (in AM and PM). May give up to 9 months.


Not recommended.

Periostat Contraindications


Nursing mothers. Infants. Children.

Periostat Boxed Warnings

Not Applicable

Periostat Warnings/Precautions


History of or active oral candidiasis. Monitor blood, renal, and hepatic function in long-term use. Avoid sun and UV light. Pregnancy (Cat.D): not recommended.

Periostat Pharmacokinetics

See Literature

Periostat Interactions


Avoid concomitant penicillins, methoxyflurane. Antacids, iron, zinc, calcium, magnesium, urinary alkalinizers reduce absorption. Carbamazepine, barbiturates, phenytoin may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.

Periostat Adverse Reactions

Adverse Reactions

Photosensitivity, GI upset, rash, blood dyscrasias; rare: hepatotoxicity.

Periostat Clinical Trials

See Literature

Periostat Note

Not Applicable

Periostat Patient Counseling

See Literature