Hyperacidity, GERD, and ulcers:

Indications for: PEPCID

Active duodenal ulcer. Reduction of the risk duodenal ulcer recurrence in adults. Active gastric ulcer. Symptomatic nonerosive gastroesophageal reflux disease (GERD). Erosive esophagitis (EE). Pathological hypersecretory conditions (eg, Zollinger-Ellison syndrome, multiple endocrine adenomas) in adults.

Adults and Children:

<40kg: use other oral forms. ≥40kg: Duodenal ulcer: 40mg once daily at bedtime or 20mg twice daily for up to 8 weeks. Recurrence: 20mg once daily at bedtime for up to 1 year or as clinically indicated. Gastric ulcer: 40mg once daily at bedtime for up to 8 weeks. GERD: 20mg twice daily for up to 6 weeks. EE: 20mg or 40mg twice daily for up to 12 weeks. Hypersecretory conditions: initially 20mg every 6hrs; individualize; max 160mg every 6hrs. Renal impairment: see full labeling.

PEPCID Contraindications:

History of serious hypersensitivity reactions to H2 receptor antagonists.

PEPCID Warnings/Precautions:

Symptomatic response does not preclude gastric malignancy; evaluate prior to initiation. Moderate to severe renal impairment (CrCl <50mL/min): reduce to ½ the dose or prolong dosing interval to 36–48hrs. Elderly: use low doses. Pregnancy. Nursing mothers.

PEPCID Classification:

H2 blocker.

PEPCID Interactions:

Concomitant dasatinib, delavirdine mesylate, cefditoren, fosamprenavir: not recommended. May alter absorption of pH-dependent drugs (eg, atazanavir, erlotinib, ketoconazole, itraconazole, ledipasvir/sofosbuvir, nilotinib, rilpivirine). May potentiate CYP1A2 substrates (eg, tizanidine); avoid; if necessary, monitor for hypotension, bradycardia, drowsiness. May give antacids concomitantly.

Adverse Reactions:

Headache, dizziness, constipation, diarrhea, inj site reactions; rare: CNS reactions, prolonged QT interval in renal impairment (moderate and severe).

How Supplied:

Tabs—30, 100; Susp—50mL; Inj—contact supplier

Pricing for PEPCID

20mg tablet (Qty: 60)
Appx. price $9
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