• Leukemias, lymphomas, and other hematologic cancers

Pentostatin Generic Name & Formulations

General Description

Pentostatin 10mg/vial; lyophilized pwd for IV inj after reconstitution; contains mannitol.

Pharmacological Class


How Supplied

Single-dose vials—1

Pentostatin Indications


Active hairy cell leukemia.

Pentostatin Dosage and Administration


Ensure adequate hydration. Give as IV bolus or infuse over 20–30 minutes after dilution. 4mg/m2 every other week. Reevaluate after 6 months; discontinue if complete or partial response not achieved; max duration of therapy 12 months. Withhold dose if ANC <200 cells/mm3; may resume when resolved.


Not recommended.

Pentostatin Contraindications

Not Applicable

Pentostatin Boxed Warnings

Not Applicable

Pentostatin Warnings/Precautions


Active infections; treat prior to initiating therapy. Withhold or discontinue therapy if severe rash or neurotoxicity develops. Renal impairment. Monitor and obtain CBCs, liver, and renal function before and during therapy. Pregnancy (Cat. D); avoid use. Nursing mothers: not recommended.

Pentostatin Pharmacokinetics

See Literature

Pentostatin Interactions


Concomitant fludarabine: not recommended. Potentiates vidarabine. Acute pulmonary toxicity and hypotension with carmustine, etoposide, and high dose cyclophosphamide (see literature).

Pentostatin Adverse Reactions

Adverse Reactions

GI upset, fever, rash, fatigue, leukopenia, pruritus, cough, myalgia, chills, headache, abdominal pain, anorexia, asthenia, stomatitis, rhinitis, dyspnea, anemia, pain, sweating, infections, thrombocytopenia.

Pentostatin Clinical Trials

See Literature

Pentostatin Note

Not Applicable

Pentostatin Patient Counseling

See Literature