Pentam 300

  • Fungal infections

Pentam 300 Generic Name & Formulations

General Description

Pentamidine isethionate 300mg/vial; lyophilized pwd for IM or IV inj after reconstitution.

Pharmacological Class

Aromatic diamidine.

How Supplied

Single-dose vials—10


Pentam 300 Indications


Pneumonia due to Pneumocystis carinii.

Pentam 300 Dosage and Administration

Adults and Children

<4months: not recommended. Give by deep IM or IV inj. If administered by IV, must infused over 60–120 minutes. ≥4months: 4mg/kg once daily for 14–21 days. Therapy >21 days has been used; but may increase toxicity risk.

Pentam 300 Contraindications

Not Applicable

Pentam 300 Boxed Warnings

Not Applicable

Pentam 300 Warnings/Precautions


Hyper- or hypotension. Ventricular tachycardia. Hypo- or hyperglycemia. Hypocalcemia. Pancreatitis. Leukopenia. Thrombocytopenia. Anemia. Hepatic or renal dysfunction. Stevens-Johnson syndrome. Monitor BP, BUN, serum creatinine, blood glucose, CBC and platelets, liver function (eg, serum bilirubin, alkaline phosphatase, AST/ALT), serum calcium, ECG. Avoid extravasation. Have resuscitation equipment available. Pregnancy (Cat.C; avoid). Nursing mothers: not recommended.

Pentam 300 Pharmacokinetics

See Literature

Pentam 300 Interactions


Additive effects with concomitant other nephrotoxic drugs (eg, aminoglycosides, amphotericin B, cisplatin, foscarnet, vancomycin); monitor closely or avoid if possible.

Pentam 300 Adverse Reactions

Adverse Reactions

Inj site reactions, severe hypotension, hypoglycemia, diabetes, acute pancreatitis, cardiac arrhythmias, nephrotoxic events (eg, renal dysfunction, elevated serum creatinine, azotemia, renal failure), leukopenia, elevated liver functions tests, anorexia/nausea, rash, pruritus.

Pentam 300 Clinical Trials

See Literature

Pentam 300 Note

Not Applicable

Pentam 300 Patient Counseling

See Literature