Pennsaid 2% Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
See Also
How Supplied
Manufacturer
Generic Availability
Pennsaid 2% Indications
Indications
Pennsaid 2% Dosage and Administration
Adult
Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals.
For relief of the pain of osteoarthritis (OA) of the knee(s):
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The recommended dose is 40 mg of diclofenac sodium (2 pump actuations) on each painful knee, 2 times a day. Apply Pennsaid to clean, dry skin evenly around front, back, and sides of the knee.
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Application of Pennsaid in an amount exceeding or less than the recommended dose has not been studied and is therefore not recommended.
Children
Pennsaid 2% Contraindications
Contraindications
Pennsaid 2% Boxed Warnings
Boxed Warning
Pennsaid 2% Warnings/Precautions
Warnings/Precautions
Pennsaid 2% Pharmacokinetics
Absorption
After administration of Pennsaid topical solution (40 mg/knee every 12 h; total daily diclofenac exposure: 80 mg/knee) for 7.5 days, the mean (SD) AUC0-12 and mean (SD) Cmax were 77.27 (49.89) ng•h/mL and 12.16 (7.66) ng/mL, respectively, on Day 1; and 204.58 (111.02) ng•h/mL and 25.24 (12.95) ng/mL, respectively, at steady state on Day 8. After administration of Pennsaid 1.5% topical solution (19.3 mg/knee every 6 h; total daily diclofenac exposure 77.2 mg/knee), the mean (SD) AUC0-12 and mean (SD) Cmax were 27.46 (23.97) ng•h/mL and 2.30 (2.02) ng/mL, respectively, on Day 1; and 141.49 (92.47) ng•h/mL and 17.04 (11.28) ng/mL, respectively, at steady state on Day 8.
Distribution
Diclofenac is more than 99% bound to human serum proteins, primarily to albumin.
Elimination
Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Little or no free unchanged diclofenac is excreted in the urine.
Pennsaid 2% Interactions
Interactions
Pennsaid 2% Adverse Reactions
Adverse Reactions
Pennsaid 2% Clinical Trials
Pennsaid 2% Note
Notes
Pennsaid 2% Patient Counseling
Cost Savings Program
Pennsaid Patient Savings & Education:
https://www.pennsaid.com/resources-and-support/patient-resources