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Paxil Suspension Generic Name & Formulations
Legal Class
Rx
General Description
Paroxetine (as HCl) 10mg/5mL; orange-flavored liq.
Pharmacological Class
SSRI.
How Supplied
CR—30; Tabs—30; Susp—250mL
Manufacturer
Generic Availability
YES
Paxil Suspension Indications
Indications
Panic disorder (PD). Social anxiety disorder (SAD). Obsessive-compulsive disorder (OCD). Generalized anxiety disorder (GAD). Posttraumatic stress disorder (PTSD).
Paxil Suspension Dosage and Administration
Adult
Give once daily, usually in the AM, adjust by 10mg/day at 1-week intervals. PD: initially 10mg/day; usual 40mg/day; max 60mg/day. SAD: 20mg/day; max 60mg/day. OCD: initially 20mg/day, usual 40mg/day; max 60mg/day. GAD or PTSD: 20mg/day; max 50mg/day. Elderly, debilitated, severe renal or hepatic impairment: initially 10mg/day; max 40mg/day.
Children
Not established.
Paxil Suspension Contraindications
Contraindications
Concomitant pimozide, thioridazine. During or within 14 days of MAOIs (including linezolid, IV methylene blue).
Paxil Suspension Boxed Warnings
Boxed Warning
Suicidal thoughts and behaviors.
Paxil Suspension Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thoughts and behavior in children and young adults; monitor all patients for clinical worsening or unusual changes. Monitor for serotonin syndrome; discontinue and treat if occurs. Screen for bipolar disorder, mania, or hypomania. Seizure disorder. Cardiac disease. Angle-closure glaucoma. Volume-depleted. Hyponatremia (esp. in elderly). Sexual dysfunction. Write ℞ for smallest practical amount. Avoid abrupt cessation; reduce dose gradually. Reevaluate periodically. Elderly. Neonates. Pregnancy (Cat.D); avoid use. Nursing mothers.
Paxil Suspension Pharmacokinetics
Elimination
Renal, fecal.
Paxil Suspension Interactions
Interactions
See Contraindications. Do not start MAOI until at least 2 weeks after discontinuing paroxetine. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Potentiation with other protein bound drugs. Increased risk of bleeding with NSAIDs, aspirin, clopidogrel, warfarin, or others that affect coagulation. May affect, or be affected by, drugs metabolized by CYP2D6 (eg, propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, risperidone). May reduce effects of tamoxifen; consider alternative antidepressant. Monitor digoxin, phenytoin, phenobarbital, theophylline, warfarin. Antagonized by fosamprenavir/ritonavir. Hormonal contraceptives and PMDD treatment: see full labeling.
Paxil Suspension Adverse Reactions
Adverse Reactions
Abnormal ejaculation, headache, nausea, somnolence, diarrhea, asthenia, dizziness, sweating, constipation, decreased appetite, insomnia, infection, decreased libido, tremor, akathisia, dry mouth, genital disorder, abnormal vision, impotence, abnormal bleeding, yawn, others; discontinuation syndrome (monitor).
Paxil Suspension Clinical Trials
See Literature
Paxil Suspension Note
Not Applicable
Paxil Suspension Patient Counseling
See Literature
Paxil Suspension Generic Name & Formulations
Legal Class
Rx
General Description
Paroxetine (as HCl) 10mg/5mL; orange-flavored liq.
Pharmacological Class
SSRI.
How Supplied
CR—30; Tabs—30; Susp—250mL
Manufacturer
Generic Availability
YES
Paxil Suspension Indications
Indications
Major depressive disorder (MDD).
Paxil Suspension Dosage and Administration
Adult
Give once daily, usually in the AM, adjust by 10mg/day at 1-week intervals. Initially 20mg/day; max 50mg/day. Elderly, debilitated, severe hepatic or renal impairment: initially 10mg/day; max 40mg/day.
Children
Not established.
Paxil Suspension Contraindications
Contraindications
Concomitant pimozide, thioridazine. During or within 14 days of MAOIs (including linezolid, IV methylene blue).
Paxil Suspension Boxed Warnings
Boxed Warning
Suicidal thoughts and behaviors.
Paxil Suspension Warnings/Precautions
Warnings/Precautions
Increased risk of suicidal thoughts and behavior in children and young adults; monitor all patients for clinical worsening or unusual changes. Monitor for serotonin syndrome; discontinue and treat if occurs. Screen for bipolar disorder, mania, or hypomania. Seizure disorder. Cardiac disease. Angle-closure glaucoma. Volume-depleted. Hyponatremia (esp. in elderly). Sexual dysfunction. Write ℞ for smallest practical amount. Avoid abrupt cessation; reduce dose gradually. Reevaluate periodically. Elderly. Neonates. Pregnancy (Cat.D); avoid use. Nursing mothers.
Paxil Suspension Pharmacokinetics
Elimination
Renal, fecal.
Paxil Suspension Interactions
Interactions
See Contraindications. Do not start MAOI until at least 2 weeks after discontinuing paroxetine. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, amphetamines, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Avoid alcohol. Potentiation with other protein bound drugs. Increased risk of bleeding with NSAIDs, aspirin, clopidogrel, warfarin, or others that affect coagulation. May affect, or be affected by, drugs metabolized by CYP2D6 (eg, propafenone, flecainide, atomoxetine, desipramine, dextromethorphan, metoprolol, nebivolol, perphenazine, tolterodine, venlafaxine, risperidone). May reduce effects of tamoxifen; consider alternative antidepressant. Monitor digoxin, phenytoin, phenobarbital, theophylline, warfarin. Antagonized by fosamprenavir/ritonavir. Hormonal contraceptives and PMDD treatment: see full labeling.
Paxil Suspension Adverse Reactions
Adverse Reactions
Abnormal ejaculation, headache, nausea, somnolence, diarrhea, asthenia, dizziness, sweating, constipation, decreased appetite, insomnia, infection, decreased libido, tremor, akathisia, dry mouth, genital disorder, abnormal vision, impotence, abnormal bleeding, yawn, others; discontinuation syndrome (monitor).
Paxil Suspension Clinical Trials
See Literature
Paxil Suspension Note
Not Applicable
Paxil Suspension Patient Counseling
See Literature
