• Mood disorders

Pamelor Generic Name & Formulations

General Description

Nortriptyline HCl 10mg, 25mg, 50mg, 75mg; caps.

Pharmacological Class


How Supplied

Caps—30; Soln—contact supplier


Pamelor Indications



Pamelor Dosage and Administration


Initially 25mg 3–4 times daily; max 150mg/day. Elderly and adolescents: 30–50mg/day in single or divided doses.


Not recommended.

Pamelor Contraindications


During or within 14 days of MAOIs. Concomitant linezolid or IV methylene blue. Acute post-MI.

Pamelor Boxed Warnings

Boxed Warning

Suicidality and antidepressant drugs.

Pamelor Warnings/Precautions


Increased risk of suicidal thinking and behavior in children, adolescents and young adults; monitor for clinical worsening and unusual changes. Monitor for emergence of serotonin syndrome; discontinue if occurs. Mania/hypomania. Bipolar disorder. Psychosis. ECT. Cardiovascular disease. Avoid in Brugada syndrome. Angle-closure glaucoma. Urinary retention. Epilepsy. Hyperthyroidism. Diabetes. Liver disorders. Monitor plasma levels if dose >100mg/day. Elderly. Pregnancy. Nursing mothers.

Pamelor Pharmacokinetics

See Literature

Pamelor Interactions


See Contraindications. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Potentiates alcohol, sympathomimetics. CNS stimulation with reserpine. Potentiated by CYP2D6 inhibitors; monitor plasma levels with quinidine, cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, propafenone, flecainide). Antagonized by barbiturates, carbamazepine. Paralytic ileus, hyperpyrexia with anticholinergics. Blocks guanethidine.

Pamelor Adverse Reactions

Adverse Reactions

Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, headache, changes in blood sugar, photosensitivity, edema, blood dyscrasias, jaundice.

Pamelor Clinical Trials

See Literature

Pamelor Note

Not Applicable

Pamelor Patient Counseling

See Literature