Oxbryta

<4yrs: not established. Use tabs or tabs for oral susp based on the ability to swallow and body weight. Disperse tabs for oral susp in room temp clear liquid (eg, water or clear soda) before swallowing. 4–<12yrs (10–<20kg): 600mg once daily; (20–<40kg): 900mg once daily; (≥40kg): 1500mg once daily. Severe hepatic impairment (10–<20kg): 300mg once daily; (20–<40kg): 600mg once daily; (≥40kg): 1000mg (two 500mg tabs) or 900mg (three 300mg tabs for oral susp) once daily. Avoid concomitant strong or moderate CYP3A4 inducers; if unavoidable with moderate CYP3A4 inducers (10–<20kg): 900mg once daily; (20–<40kg): 1200mg once daily; (≥40kg): 2000mg (four 500mg tabs) or 2100mg (seven 300mg tabs for oral susp) once daily; if unavoidable with strong CYP3A4 inducers (10–<20kg): 900mg once daily; (20–<40kg): 1500mg once daily; (≥40kg): 2500mg (five 500mg tabs) or 2400mg (eight 300mg tabs for oral susp) once daily.