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Oxandrolone Generic Name & Formulations
Legal Class
CIII
General Description
Oxandrolone 2.5mg+, 10mg; tabs (+scored).
Pharmacological Class
Androgen.
How Supplied
Contact supplier
Manufacturer
Oxandrolone Indications
Indications
As an adjunct to promote weight gain after extensive surgery, chronic infections, severe trauma, and without definite cause, to offset protein catabolism associated with prolonged corticosteroid administration, and for relief of osteoporotic bone pain.
Oxandrolone Dosage and Administration
Adult
Individualize. 2.5–20mg daily given in 2–4 divided doses. Treat for 2–4 weeks; may repeat intermittently as needed. Elderly: 5mg twice daily.
Children
≤0.1mg/kg/day; may repeat intermittently as needed.
Oxandrolone Contraindications
Contraindications
Breast (women with hypercalcemia, men) or prostate carcinoma. Nephrosis. Hypercalemia. Pregnancy (Cat.X).
Oxandrolone Boxed Warnings
Boxed Warning
Peliosis hepatis. Liver cell tumors. Blood lipid changes.
Oxandrolone Warnings/Precautions
Warnings/Precautions
Risk of peliosis hepatis, liver cell tumors, blood lipid changes associated with atherosclerosis. Discontinue if cholestatic hepatitis, jaundice, abnormal liver function tests, or hypercalcemia occurs. Cardiovascular disease. COPD. Edematous conditions. Hepatic or renal dysfunction. Monitor hepatic function, serum lipids, Hgb/Hct, and bone age (children) periodically. Monitor for signs of virilization in women; discontinue if mild virilism occurs to prevent irreversible condition. Elderly. Young children. Nursing mothers: not recommended.
Oxandrolone Pharmacokinetics
See Literature
Oxandrolone Interactions
Interactions
May potentiate warfarin (monitor INR/PT), oral hypoglycemics. Increased risk of edema with ACTH, corticosteroids. May suppress clotting factors II, V, VII and X. May decrease thyroxine-binding globulin and radioactive iodine uptake.
Oxandrolone Adverse Reactions
Adverse Reactions
Peliosis hepatis, premature epiphyseal closure in children, edema, dyslipidemia, hepatic carcinoma, prostatic hypertrophy or carcinoma, gynecomastia, priapism, oligospermia, jaundice, hirsutism, virilization, menstrual irregularities, male pattern baldness, acne, polycythemia, excitation, depression, altered libido, fluid and electrolyte disturbances, decreased glucose tolerance.
Oxandrolone Clinical Trials
See Literature
Oxandrolone Note
Notes
Formerly known under the brand name Oxandrin.
Oxandrolone Patient Counseling
See Literature
