Oxandrolone

— THERAPEUTIC DISORDERS TREATED —
  • Hypogonadism

Oxandrolone Generic Name & Formulations

General Description

Oxandrolone 2.5mg+, 10mg; tabs (+scored).

Pharmacological Class

Androgen.

How Supplied

Contact supplier

Oxandrolone Indications

Indications

As an adjunct to promote weight gain after extensive surgery, chronic infections, severe trauma, and without definite cause, to offset protein catabolism associated with prolonged corticosteroid administration, and for relief of osteoporotic bone pain.

Oxandrolone Dosage and Administration

Adult

Individualize. 2.5–20mg daily given in 2–4 divided doses. Treat for 2–4 weeks; may repeat intermittently as needed. Elderly: 5mg twice daily.

Children

≤0.1mg/kg/day; may repeat intermittently as needed.

Oxandrolone Contraindications

Contraindications

Breast (women with hypercalcemia, men) or prostate carcinoma. Nephrosis. Hypercalemia. Pregnancy (Cat.X).

Oxandrolone Boxed Warnings

Boxed Warning

Peliosis hepatis. Liver cell tumors. Blood lipid changes.

Oxandrolone Warnings/Precautions

Warnings/Precautions

Risk of peliosis hepatis, liver cell tumors, blood lipid changes associated with atherosclerosis. Discontinue if cholestatic hepatitis, jaundice, abnormal liver function tests, or hypercalcemia occurs. Cardiovascular disease. COPD. Edematous conditions. Hepatic or renal dysfunction. Monitor hepatic function, serum lipids, Hgb/Hct, and bone age (children) periodically. Monitor for signs of virilization in women; discontinue if mild virilism occurs to prevent irreversible condition. Elderly. Young children. Nursing mothers: not recommended.

Oxandrolone Pharmacokinetics

See Literature

Oxandrolone Interactions

Interactions

May potentiate warfarin (monitor INR/PT), oral hypoglycemics. Increased risk of edema with ACTH, corticosteroids. May suppress clotting factors II, V, VII and X. May decrease thyroxine-binding globulin and radioactive iodine uptake.

Oxandrolone Adverse Reactions

Adverse Reactions

Peliosis hepatis, premature epiphyseal closure in children, edema, dyslipidemia, hepatic carcinoma, prostatic hypertrophy or carcinoma, gynecomastia, priapism, oligospermia, jaundice, hirsutism, virilization, menstrual irregularities, male pattern baldness, acne, polycythemia, excitation, depression, altered libido, fluid and electrolyte disturbances, decreased glucose tolerance.

Oxandrolone Clinical Trials

See Literature

Oxandrolone Note

Notes

Formerly known under the brand name Oxandrin.

Oxandrolone Patient Counseling

See Literature