Bacterial infections:

Indications for Oxacillin Inj:

Susceptible infections due to penicillinase-producing staphylococci.

Adult:

Give by IM gluteal inj, or slow IV inj over 10 mins, or IV drip. Mild-to-moderate infections: 250–500mg IM or IV every 4–6 hours. Severe infections: 1g IM or IV every 4–6 hours; treat for at least 14 days, then continue for at least 48 hours after becoming afebrile, asymptomatic, or (–) cultures. Endocarditis or osteomyelitis: may need longer therapy; see literature. Switch to oral therapy as soon as clinically indicated.

Children:

Give by IM gluteal inj, or slow IV inj over 10 mins, or IV drip. Premature and neonates: 25mg/kg/day IM or IV. Infants and children <40kg: Mild-to-moderate infections: 50mg/kg/day IM or IV in divided doses every 6 hours; severe infections: 100mg/kg/day IM or IV in divided doses every 4–6 hours; treat for at least 14 days, then continue for at least 48 hours after becoming afebrile, asymptomatic, or (–) cultures. Endocarditis or osteomyelitis: may need longer therapy; see literature. Switch to oral therapy as soon as clinically indicated.

Warnings/Precautions:

Cephalosporin or other allergy: not recommended. Asthma. Renal impairment: consider dose reduction. Do CBCs, BUN, urinalysis, creatinine levels prior to and weekly during therapy. Monitor renal, hepatic and hematopoietic function in prolonged use. Elderly (esp. IV route). Newborns (monitor). Pregnancy (Cat.B). Nursing mothers.

Pharmacologic Class:

Penicillinase-resistant penicillin.

Interactions:

May be antagonized by tetracycline; avoid. Potentiated by probenecid.

Adverse Reactions:

Inj site reactions, rash, serum sickness, GI upset, anaphylaxis, neuropathy, nephropathy, blood dyscrasias, hepatotoxicity.

Note:

Formerly known under the brand name Bactocill.

How Supplied:

Contact supplier.