• Constipation and bowel cleansers

Osmoprep Generic Name & Formulations

General Description

Sodium phosphate (as monobasic monohydrate and dibasic anhydrous) 1.5g; tabs; gluten-free.

Pharmacological Class

Osmotic laxative.

How Supplied


Osmoprep Indications


Bowel cleansing prior to colonoscopy.

Osmoprep Dosage and Administration


≥18yrs: Evening before colonoscopy: 4 tabs with 8oz of clear liq every 15 mins for a total of 20 tabs; repeat on day of colonoscopy 3–5 hrs before procedure for a total of 12 tabs. Wait 7 days before retreating.


<18yrs: not recommended.

Osmoprep Contraindications


Biopsy-proven acute phosphate nephropathy.

Osmoprep Boxed Warnings

Boxed Warning

Renal disease and acute phosphate nephropathy.

Osmoprep Warnings/Precautions


Elderly, hypovolemia, increased bowel transit time, active colitis, baseline kidney disease: increased risk of acute phosphate nephropathy. Severe renal insufficiency (CrCl<30mL/min). Impaired renal function. History of acute phosphate nephropathy. CHF. Unstable angina. Arrhythmias (consider pre-dose and post-colonoscopy ECGs). History of cardiomyopathy. Prolonged QT. Recent MI. Ascites. Gastric retention. Ileus or acute obstruction or pseudo-obstruction. Gastric bypass or stapling surgery. Severe chronic constipation. Bowel perforation. Toxic megacolon. Hypomotility syndrome. Inflammatory bowel disease. Correct electrolyte abnormalities before use. Consider doing baseline and post-colonoscopy labs in patients at increased risk. History or risk of seizures. Maintain adequate hydration. Pregnancy (Cat.C).

Osmoprep Pharmacokinetics

See Literature

Osmoprep Interactions


Avoid concomitant purgative agents (esp. sodium phosphate). Caution with drugs that prolong QT interval, affect electrolytes or renal function (eg, diuretics, ACEIs, ARBs, NSAIDs), or lower seizure threshold. May reduce drug absorption.

Osmoprep Adverse Reactions

Adverse Reactions

Abdominal bloating/pain, nausea, vomiting, electrolyte imbalances, dizziness, headache; rare: renal failure, acute phosphate nephropathy, nephrocalcinosis.

Osmoprep Clinical Trials

See Literature

Osmoprep Note

Not Applicable

Osmoprep Patient Counseling

See Literature