Musculoskeletal pain:

Indications for Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg:

Painful musculoskeletal conditions.

Adult Dosage:

1–2 tabs 3–4 times daily.

Children Dosage:

Not recommended.

Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg Contraindications:

NSAID allergy. Varicella or influenza in teenagers. Glaucoma. Achalasia. GU or GI obstruction. Myasthenia gravis.

Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg Warnings/Precautions:

Coronary disease, insufficiency or tachycardia. History of bronchospasm. Peptic ulcer. Coagulation disorders. Monitor blood pressure, BUN, uric acid levels. Pregnancy (Cat.C). Nursing mothers.

Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg Classification:

Anticholinergic + salicylate + methylxanthine.

Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg Interactions:

Increased risk of GI bleed/ulcer with alcohol, aspirin, NSAIDs, corticosteroids, anticoagulants. Potentiates oral hypoglycemics, anticholinergics, protein-bound drugs (eg, warfarin). Antagonizes steroids, barbiturates, phenylbutazone, uricosurics. Tremor and mental confusion with propoxyphene.

Adverse Reactions:

Tachycardia, transient dizziness or syncope, GI upset/bleed, anticholinergic effects (eg, dry mouth, blurred vision, increased intraocular pressure, urinary retention), weakness, headache, rash, blood dyscrasias.


Formerly known under the brand names Norgesic (25/385/30); Norgesic Forte (50/770/60).

How Supplied:

Contact supplier.