Musculoskeletal pain:

Indications for Orphenadrine 25mg/Aspirin 385mg/Caffeine 30mg:

Painful musculoskeletal conditions.


1–2 tabs 3–4 times daily.


Not recommended.


NSAID allergy. Varicella or influenza in teenagers. Glaucoma. Achalasia. GU or GI obstruction. Myasthenia gravis.


Coronary disease, insufficiency or tachycardia. History of bronchospasm. Peptic ulcer. Coagulation disorders. Monitor blood pressure, BUN, uric acid levels. Pregnancy (Cat.C). Nursing mothers.

Pharmacologic Class:

Anticholinergic + salicylate + methylxanthine.


Increased risk of GI bleed/ulcer with alcohol, aspirin, NSAIDs, corticosteroids, anticoagulants. Potentiates oral hypoglycemics, anticholinergics, protein-bound drugs (eg, warfarin). Antagonizes steroids, barbiturates, phenylbutazone, uricosurics. Tremor and mental confusion with propoxyphene.

Adverse Reactions:

Tachycardia, transient dizziness or syncope, GI upset/bleed, anticholinergic effects (eg, dry mouth, blurred vision, increased intraocular pressure, urinary retention), weakness, headache, rash, blood dyscrasias.


Formerly known under the brand names Norgesic (25/385/30); Norgesic Forte (50/770/60).

How Supplied:

Contact supplier.