• Prostate and other male cancers

Orgovyx Generic Name & Formulations

General Description

Relugolix 120mg; tabs.

Pharmacological Class

GnRH antagonist.

How Supplied

Tabs—30; Blister pack—9


Generic Availability


Orgovyx Indications


Advanced prostate cancer.

Orgovyx Dosage and Administration


Swallow whole. Initially 360mg on the first day, then 120mg once daily. If treatment is interrupted for >7days, restart at 360mg on the first day, then 120mg once daily. Avoid concomitant oral P-gp inhibitors; if unavoidable, take Orgovyx first and separate dosing by ≥6hrs; may interrupt Orgovyx for up to 2 weeks for a short treatment with certain P-gp inhibitors. Avoid concomitant with combined P-gp and strong CYP3A inducers; if unavoidable, increase Orgovyx dose to 240mg once daily. After discontinuation of combined inducers, resume at 120mg once daily.


Not established.

Orgovyx Contraindications

Not Applicable

Orgovyx Boxed Warnings

Not Applicable

Orgovyx Warnings/Precautions


Congenital long QT syndrome. CHF. Correct electrolyte abnormalities. Consider periodic monitoring of ECGs and electrolytes. Monitor serum PSA periodically; if PSA increases, measure serum testosterone levels. Embryo-fetal toxicity. Advise males with female partners of reproductive potential to use effective contraception during and for 2 weeks after the last dose. Pregnancy. Nursing mothers.

Orgovyx Pharmacokinetics

See Literature

Orgovyx Interactions


Caution with concomitant drugs known to prolong the QT interval. Potentiated by P-gp inhibitors; avoid (see Adults). Antagonized by combined P-gp and strong CYP3A inducers; avoid (see Adults). May affect results of diagnostic tests of the pituitary gonadotropic and gonadal functions during and after Orgovyx.

Orgovyx Adverse Reactions

Adverse Reactions

Hot flush, increased glucose, increased triglycerides, musculoskeletal pain, decreased hemoglobin, increased ALT/AST, fatigue, constipation, diarrhea.

Orgovyx Clinical Trials

See Literature

Orgovyx Note

Not Applicable

Orgovyx Patient Counseling

See Literature