Bacterial infections:

Indications for ORBACTIV:

Acute bacterial skin and skin structure infections (ABSSSI) caused by the following susceptible Gram (+) microorganisms: Staphylococcus aureus (including MRSA and MSSA), Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus anginosus Group (including Streptococcus anginosus, Streptococcus intermedius, Streptococcus constellatus) and Enterococcus faecalis (vancomycin-susceptible isolates only).

Adult Dosage:

Give by IV infusion over 3hrs. ≥18yrs: 1200mg as a single dose.

Children Dosage:

<18yrs: not established.

ORBACTIV Contraindications:

Use of IV unfractionated heparin sodium for 120hrs (5 days) after oritavancin administration.

ORBACTIV Warnings/Precautions:

History of glycopeptide allergy. Discontinue immediately if acute hypersensitivity reaction occurs. Consider slowing or stopping infusion if infusion-related reactions occur. Risk of Clostridium difficile-associated diarrhea; evaluate and may need to discontinue if occurs. Monitor for signs/symptoms of osteomyelitis; use alternative therapy if suspected or diagnosed. Severe hepatic or renal impairment: not studied. Pregnancy. Nursing mothers.

ORBACTIV Classification:


ORBACTIV Interactions:

Increased risk of bleeding with concomitant warfarin; may prolong aPTT for up to 120hrs, PT/INR for up to 12hrs, and ACT for up to 24hrs; monitor for bleeding. Avoid concomitant drugs with a narrow therapeutic window that are metabolized by the affected CYP450 enzymes. May increase concentrations of CYP2C9/CYP2C19 substrates. May decrease concentrations of CYP3A4/CYP2D6 substrates. May interfere with coagulation tests; consider non-phospholipid dependent test (eg, Factor Xa assay) or alternative anticoagulant not requiring aPTT monitoring.

Adverse Reactions:

Headache, nausea, vomiting, limb and subcutaneous abscesses, diarrhea; infusion-related reactions.

Generic Drug Availability:


How Supplied:

Single-dose vials—3

Pricing for ORBACTIV

400mg vial (Qty: 1)
Appx. price $1025