Orbactiv Generic Name & Formulations
Oritavancin 400mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains mannitol; preservative-free.
Susceptible acute bacterial skin and skin structure infections (ABSSSI).
Orbactiv Dosage and Administration
Give by IV infusion over 3hrs. ≥18yrs: 1200mg as a single dose.
<18yrs: not established.
Use of IV unfractionated heparin sodium for 120hrs (5 days) after oritavancin administration.
Orbactiv Boxed Warnings
History of glycopeptide allergy. Discontinue immediately if acute hypersensitivity reaction occurs. Stop or slow the infusion if infusion-related reactions occur. Evaluate if Clostridioides difficile-associated diarrhea is suspected or confirmed. Monitor for osteomyelitis; use alternative therapy if suspected or diagnosed. Severe hepatic or renal impairment: not studied. Pregnancy. Nursing mothers.
Increased risk of bleeding with concomitant warfarin; may prolong aPTT for up to 120hrs, PT/INR for up to 12hrs, and ACT for up to 24hrs; monitor for bleeding. Avoid concomitant with drugs that are predominantly metabolized by one of the affected CYP450 enzymes. May increase concentrations of CYP2C9/CYP2C19 substrates. May decrease concentrations of CYP3A4/CYP2D6 substrates. May prolong certain lab coagulation tests; consider non-phospholipid dependent test (eg, Factor Xa assay) or alternative anticoagulant not requiring aPTT monitoring.
Orbactiv Adverse Reactions
Headache, nausea, vomiting, limb and subcutaneous abscesses, diarrhea; infusion-related reactions.
Orbactiv Clinical Trials
Orbactiv Patient Counseling