• Corticosteroid-responsive disorders

Orapred Generic Name & Formulations

General Description

Prednisolone (as sodium phosphate) 15mg/5mL; soln; dye-free; grape flavor; contains alcohol.

Pharmacological Class


See Also

How Supplied

Soln—237mL; Tabs—48

Generic Availability


Orapred Indications


Steroid-responsive disorders.

Orapred Dosage and Administration


See full labeling. Tabs: swallow whole or dissolve on tongue; do not break or use partial tabs. Initially 5–60mg/day.


See full labeling. Tabs: swallow whole or dissolve on tongue; do not break or use partial tabs. Initially 0.14–2mg/kg per day in 3–4 divided doses.

Orapred Contraindications


Systemic mycoses. Live vaccinations. Cerebral malaria.

Orapred Boxed Warnings

Not Applicable

Orapred Warnings/Precautions


Tuberculosis. Latent infection (esp. amebiasis). Hypo- or hyperthyroidism. Cirrhosis. Ocular herpes simplex, optic neuritis: not recommended. Avoid exposure to chickenpox or measles; consider prophylactic passive immune therapy if exposure occurs. Renal insufficiency. Ulcerative colitis if perforation pending. Diverticulitis. Peptic ulcer. Hypertension. CHF. Osteoporosis. Diabetes. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. Alternate, intermittent or single-daily doses at 8AM minimize adrenal suppression. Monitor weight, growth, fluid and electrolyte balance, and intraocular pressure. Emotional instability. Psychotic tendencies. Embryo-fetal toxicity. Pregnancy (esp. 1st trimester): monitor. Nursing mothers: use lowest dose.

Orapred Pharmacokinetics

See Literature

Orapred Interactions


Effects may be decreased by hepatic enzyme inducers (eg, barbiturates, hydantoins, rifampin). May be potentiated by ketoconazole estrogens. Acute myopathy with neuromuscular blockers. Avoid aspirin. Cyclosporine: both drugs potentiated and seizures reported. Monitor warfarin, antidiabetic agents. Avoid anticholinesterases. Monitor if given with potassium-depleting agents, digoxin.

Orapred Adverse Reactions

Adverse Reactions

HPA axis suppression, masks infection, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.

Orapred Clinical Trials

See Literature

Orapred Note

Not Applicable

Orapred Patient Counseling

See Literature