Orapred Odt

  • Corticosteroid-responsive disorders

Orapred Odt Generic Name & Formulations

General Description

Prednisolone (as sodium phosphate) 10mg, 15mg, 30mg; orally-disintegrating tabs; grape flavor.

Pharmacological Class


See Also

How Supplied

Soln—237mL; Tabs—48

Generic Availability


Orapred Odt Indications


Steroid-responsive disorders.

Orapred Odt Dosage and Administration


See full labeling. Tabs: swallow whole or dissolve on tongue; do not break or use partial tabs. Initially 5–60mg/day.


See full labeling. Tabs: swallow whole or dissolve on tongue; do not break or use partial tabs. Initially 0.14–2mg/kg per day in 3–4 divided doses.

Orapred Odt Contraindications


Systemic mycoses. Live vaccinations. Cerebral malaria.

Orapred Odt Boxed Warnings

Not Applicable

Orapred Odt Warnings/Precautions


Tuberculosis. Latent infection (esp. amebiasis). Hypo- or hyperthyroidism. Cirrhosis. Ocular herpes simplex, optic neuritis: not recommended. Avoid exposure to chickenpox or measles; consider prophylactic passive immune therapy if exposure occurs. Renal insufficiency. Ulcerative colitis if perforation pending. Diverticulitis. Peptic ulcer. Hypertension. CHF. Osteoporosis. Diabetes. Supplement with additional steroids in physiologic stress. Avoid abrupt cessation. Alternate, intermittent or single-daily doses at 8AM minimize adrenal suppression. Monitor weight, growth, fluid and electrolyte balance, and intraocular pressure. Emotional instability. Psychotic tendencies. Embryo-fetal toxicity. Pregnancy (esp. 1st trimester): monitor. Nursing mothers: use lowest dose.

Orapred Odt Pharmacokinetics

See Literature

Orapred Odt Interactions


Effects may be decreased by hepatic enzyme inducers (eg, barbiturates, hydantoins, rifampin). May be potentiated by ketoconazole estrogens. Acute myopathy with neuromuscular blockers. Avoid aspirin. Cyclosporine: both drugs potentiated and seizures reported. Monitor warfarin, antidiabetic agents. Avoid anticholinesterases. Monitor if given with potassium-depleting agents, digoxin.

Orapred Odt Adverse Reactions

Adverse Reactions

HPA axis suppression, masks infection, increased susceptibility to infection, glaucoma, cataracts, secondary infections, hypokalemia, hypocalcemia, hypernatremia, hypertension, psychic disorders, myopathy, osteoporosis, peptic ulcer, dermal atrophy, increased intracranial pressure, carbohydrate intolerance.

Orapred Odt Clinical Trials

See Literature

Orapred Odt Note

Not Applicable

Orapred Odt Patient Counseling

See Literature