• Imaging agents

Optison Generic Name & Formulations

General Description

Perflutren 0.22±0.11mg, protein-type A microspheres 5–8x10^8, human albumin 10mg; per mL; susp for IV inj.

Pharmacological Class

Contrast media.

How Supplied

Single-patient use vials (3mL)—5, 18


Generic Availability


Mechanism of Action

Optison microspheres create an echogenic contrast effect in the blood. The acoustic impedance of the microspheres is much lower than that of the blood. Therefore, impinging ultrasound waves are scattered and reflected at the microsphere-blood interface and ultimately may be visualized in the ultrasound image.

Optison Indications


To opacify the left ventricle and to improve the delineation of the left ventricular endocardial borders in patients with suboptimal echocardiograms. 

Optison Dosage and Administration


Give by IV inj into peripheral vein. Initially 0.5mL; may repeat doses in 0.5mL increments, if inadequate contrast enhancement. Max total dose: 5mL in any 10-min period or 8.7mL in any single patient study. 


Not established.

Optison Contraindications

Not Applicable

Optison Boxed Warnings

Boxed Warning

Serious cardiopulmonary reactions.

Optison Warnings/Precautions


Have resuscitation equipment readily available. Increased risk for serious cardiopulmonary reactions in those with unstable conditions (eg, acute MI, acute coronary artery syndromes, worsening or unstable CHF, serious ventricular arrhythmias). Monitor for acute and hypersensitivity reactions. Cardiac shunt; assess for embolic phenomena after administration. Mechanical indices >0.8: not recommended. Contains human albumin; risk for viral transmission (eg, Creutzfeldt-Jakob disease). Elderly. Pregnancy. Nursing mothers. 

Optison Pharmacokinetics


Pulmonary. Half-life: 1.3±0.69 minutes.

Optison Interactions

Not Applicable

Optison Adverse Reactions

Adverse Reactions

Headache, nausea, vomiting, warm sensation, flushing, dizziness; cardiopulmonary reactions (may be fatal), hypersensitivity reactions. 

Optison Clinical Trials

See Literature

Optison Note

Not Applicable

Optison Patient Counseling

See Literature