• Diabetes

Onglyza Generic Name & Formulations

General Description

Saxagliptin 2.5mg, 5mg; tabs.

Pharmacological Class

Dipeptidyl peptidase-4 (DPP-4) inhibitor.

How Supplied

Tabs—30, 90

Generic Availability


Onglyza Indications


Adjunct to diet and exercise in type 2 diabetes, as monotherapy or combination therapy.

Limitations of Use

Not for treatment of type 1 diabetes or diabetic ketoacidosis.

Onglyza Dosage and Administration


Swallow whole. 2.5mg or 5mg once daily. Moderate or severe renal impairment or ESRD requiring hemodialysis (CrCl ≤50mL/min), or concomitant strong CYP3A4/5 inhibitors: 2.5mg once daily. Give dose after hemodialysis.


<18yrs: not established.

Onglyza Contraindications

Not Applicable

Onglyza Boxed Warnings

Not Applicable

Onglyza Warnings/Precautions


Assess renal function before starting therapy and periodically thereafter. Monitor for signs/symptoms of pancreatitis, serious hypersensitivity reactions, severe joint pain, or bullous pemphigoid; discontinue if suspected or occurs. Consider risks/benefits in patients with known risk factors for heart failure; monitor for signs/symptoms; evaluate and consider discontinuing if develops. History of angioedema to other DPP4 inhibitors. Pregnancy. Nursing mothers.

Onglyza Pharmacokinetics

See Literature

Onglyza Interactions


Potentiated by strong CYP3A4/5 inhibitors (eg, ketoconazole, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin). May need lower dose of concomitant sulfonylurea or insulin to reduce risk of hypoglycemia.

Onglyza Adverse Reactions

Adverse Reactions

Upper respiratory tract infection, UTI, headache, peripheral edema (with thiazolidinediones); hypoglycemia (with sulfonylureas or insulin), hypersensitivity reactions (eg, anaphylaxis, angioedema, exfoliative skin conditions), pancreatitis, heart failure, severe and disabling arthralgia, bullous pemphigoid.

Onglyza Clinical Trials

See Literature

Onglyza Note

Not Applicable

Onglyza Patient Counseling

See Literature