Leukemias, lymphomas, and other hematologic cancers:

Recent Updates:

Added monitor for hepatotoxicity and abnormal liver function.

Indications for ONCASPAR:

First-line acute lymphoblastic leukemia (including patients with asparaginase hypersensitivity).

Adults and Children:

Give by IV inj over 1–2hrs or by IM inj (max 2mL/inj site). 2500 IU/m2 no more frequently than every 14 days.

Contraindications:

History of pancreatitis, serious hemorrhage, or thrombosis with prior L-asparaginase therapy.

Warnings/Precautions:

Have resuscitation equipment available and observe patient for 1hr post-dose. Monitor serum glucose, coagulation parameters. Discontinue if serious allergic reactions, thrombotic events, or pancreatitis occur. Monitor for hepatotoxicity and abnormal liver function. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacologic Class:

Enzyme.

Adverse Reactions:

Allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, CNS thrombosis, coagulopathy, hyperbilirubinemia, elevated transaminases, hyperlipidemia.

How Supplied:

Single-use vial (5mL)—1