Leukemias, lymphomas, and other hematologic cancers:
Added monitor for hepatotoxicity and abnormal liver function.
Indications for ONCASPAR:
First-line acute lymphoblastic leukemia (including patients with asparaginase hypersensitivity).
Adults and Children:
Give by IV inj over 1–2hrs or by IM inj (max 2mL/inj site). 2500 IU/m2 no more frequently than every 14 days.
History of pancreatitis, serious hemorrhage, or thrombosis with prior L-asparaginase therapy.
Have resuscitation equipment available and observe patient for 1hr post-dose. Monitor serum glucose, coagulation parameters. Discontinue if serious allergic reactions, thrombotic events, or pancreatitis occur. Monitor for hepatotoxicity and abnormal liver function. Pregnancy (Cat.C). Nursing mothers: not recommended.
Allergic reactions (including anaphylaxis), hyperglycemia, pancreatitis, CNS thrombosis, coagulopathy, hyperbilirubinemia, elevated transaminases, hyperlipidemia.
Single-use vial (5mL)—1